ISSN: 2228-5660    eISSN: 2228-5652  
Bioimpacts. 2014;4(1):15-20.
doi:10.5681/bi.2014.003
PMID: 24790894
PMCID: PMC4005278

Scopus id: 84900495085

Review

The potential effectiveness of nanoparticles as radio sensitizers for radiotherapy

Mohammad Babaei 1, Maryam Ganjalikhani 2 *

1 Department of Radiotherapy Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
2 Tehran University of Medical Sciences, Tehran, Iran

Abstract

Introduction: Application of nanoparticles as radio sensitizer is a promising field to improve efficiency of radiotherapy.
Methods: This study was conducted to review nano radio sensitizers. PubMed, Ovid Medline, Science Direct, Scopus, ISI web of knowledge, and Springer databases were searched from 2000 to May 2013 to identify relevant studies. Search was restricted to English language.
Results: We included any study that evaluated nanoparticles, volunteer of radio enhancement at radiotherapy on animals or cell lines. Nanoparticles can increase radio sensitivity of tumor cells. This effect was shown in vivo and in vitro, at kilovltage or megavoltage energies, in 24 reviewed studies. Focus of studies was on gold nanoparticles. Radio sensitizing effects of nanoparticles depend on nanoparticles’ size, type, concentration, intracellular localization, used irradiation energy and tested cell line.
Conclusion: Literature suggests potency of nanoparticles for increasing cell radio sensitivity. Reviewed results are promising and warrant future clinical trials.
First name
 
Last name
 
Email address
 
Comments
 
Security code


Submitted: 19 Sep 2013


EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)

Abstract Page Views: 160
PDF Downloads: 152
Full Text Views: 0