Bioimpacts. 2013;3(2):53-65.
doi: 10.5681/bi.2013.007
PMID: 23878788
PMCID: PMC3713871
Scopus id: 84881502609
  Abstract View: 559
  PDF Download: 405


Nanomaterials as Non-viral siRNA Delivery Agents for Cancer Therapy


Gene therapy has been recently shown as a promising tool for cancer treatment as nanotechnology-based safe and effective delivery methods are developed. Generally, genes are wrapped up in extremely tiny nanoparticles which could be taken up easily by cancer cells, not to their healthy neighboring cells. Several nanoparticle systems have been investigated primarily to address the problems involved in other methods of gene delivery and observed improved anticancer efficacy suggesting that nanomedicine provides novel opportunities to safely deliver genes, thus treat cancer. In this review, various nanoparticle types and related strategies, used in gene delivery for cancer treatment, have been discussed.
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Submitted: 11 Nov 2012
Revised: 22 Dec 2012
First published online: 14 Jan 2013
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