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Bioimpacts. 2011;1(2): 129-134.
doi: 10.5681/bi.2011.017
PMID: 23678417
PMCID: PMC3648952
  Abstract View: 1631
  PDF Download: 911

Original Research

Apoptosis Resistance in Endometriosis

Ali Salmassi 1*, Bengi Acar-Perk 1, Andreas G. Schmutzler 1, Kerstin Koch 1, Frank Püngel 1, Walter Jonat 1, Liselotte Mettler 1

1 Centre for Reproductive Medicine, Women’s Hospital, Christian-Albrechts-University, Kiel, Germany
*Corresponding Author: Email:

Abstract

Introduction: In a cytological analysis of endometriotic lesions neither granulocytes nor cytotoxic T-cells appear in an appreciable number. Based on this observation we aimed to know, whether programmed cell death plays an essential role in the destruction of dystopic endometrium. Disturbances of the physiological mechanisms of apoptosis, a persistence of endometrial tissue could explain the disease. Another aspect of this consideration is the proliferation competence of the dystopic mucous membrane. Methods: Endometriotic lesions of 15 patients were examined through a combined measurement of apoptosis activity with the TUNEL technique (terminal deoxyribosyltransferase mediated dUTP Nick End Labeling) and the proliferation activity (with the help of the Ki-67-Antigens using the monoclonal antibody Ki-S5). Results: Twelve out of 15 women studied showed a positive apoptotic activity of 3-47% with a proliferation activity of 2-25% of epithelial cells. Therefore we concluded that the persistence of dystopic endometrium requires proliferative epithelial cells from middle to lower endometrial layers. Conclusion: A dystopia misalignment of the epithelia of the upper layers of the functionalism can be rapidly eliminated by apoptotic procedures.
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Submitted: 14 May 2011
Revision: 30 Jun 2011
Accepted: 12 Jul 2011
ePublished: 06 Aug 2011
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