Jaleh Barar  , Mohammad A. Rafi, Mohammad M. Pourseif, Yadollah Omidi*
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Mohammad Reza Asgharzadeh, Jaleh Barar , Mohammad M. Pourseif, Morteza Eskandani, Mojtaba Jafari Niya, Mohammad Reza Mashayekhi, Yadollah Omidi*
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Mohammad Mostafa Pourseif, Gholamali Moghaddam*, Hossein Daghighkia, Ahmad Nematollahi, Yadollah Omidi*
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Sepideh Parvizpour, Jafar Razmara, Mohammad M. Pourseif, Yadollah Omidi*
Using
immunoinformatic tools, a multi-epitope peptide vaccine (consisting of CD8+cytotoxic T lymphocytes epitopes, helper epitopes and
adjuvant) was designed to combat the triple-negative breast cancer. The vaccine
showed acceptable immunogenicity and potential to stimulate both cellular and
humoral immune responses.
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Mohammad Reza Asgharzadeh, Mohammad M. Pourseif, Jaleh Barar , Morteza Eskandani, Mojtaba Jafari Niya, Mohammad Reza Mashayekhi, Yadollah Omidi*
Increased expression of TSGA10 associated with the reduced metastasis in the MDA-MB-231 cells. TSGA10 showed interaction with HIF-1α with high affinity. TSGA10 expression is altered under the hypoxia, indicating its potential as a bio-target for cancer therapy.
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Mohammad Mostafa Pourseif, Mitra Yousefpour*, Mohammad Aminianfar, Gholamali Moghaddam, Ahmad Nematollahi
The minigene vaccine construct is designed based on the B and T cell epitopes of E. granulosus enolase protein, and ligands for TLR-2 and TLR-4. The minigene vaccine showed stable properties for proper binding with the Toll-like receptors.
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Original Research
COVID-19
Mohammad Mostafa Pourseif , Sepideh Parvizpour, Behzad Jafari, Jaber Dehghani , Behrouz Naghili, Yadollah Omidi*
Immunodominant T-cell epitopes of SARS-CoV-2 spike protein with the highest population coverage were predicted by analyzing peptide binders and consensus rank (CR) score. Multi-method B-cell epitope prediction approach was used to find B-cell immunodominant regions of spike protein. Upon the high immune-potent regions of the antigen(s), self-amplifying mRNA and peptide-based vaccines were designed.
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