1. Enzyme replacement therapies: what is the best option?

Azam Safary , Mostafa Akbarzadeh Khiavi , Rahimeh Mousavi, Jaleh Barar , Mohammad A Rafi*

Bioimpacts. 2018;8(3): 153-157. doi: 10.15171/bi.2018.17

PMCID: PMC6128977 PMID: 30211074 Scopus ID: 85050655722

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Original Research

2. PEGylated gold nanoparticles-ribonuclease induced oxidative stress and apoptosis in colorectal cancer cells

Mostafa Akbarzadeh Khiavi , Azam Safary , Jaleh Barar , Hamed Farzi-Khajeh, Abolfazl Barzegari, Rahimeh Mousavi, Mohammad Hossein Somi* , Yadollah Omidi*

Bioimpacts. 2020;10(1): 27-36. doi: 10.15171/bi.2020.04

PMCID: PMC6977588 PMID: 31988854 Scopus ID: 85078959970

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The current study introduces an efficient ROS-responsive enzyme-based nanobiosystem and its biological impact in colon cancer therapy. Based on physicochemical properties, AuNPs-PEG-RNase A effectively induced apoptosis in SW-480 colon cancer cells and resulted in a significant reduction in cancer cell viability.

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