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Bioimpacts. 2015;5(1): 3-8. doi: 10.15171/bi.2015.02
PMID: 25901291        PMCID: PMC4401166

Original Research

Metformin attenuates myocardial remodeling and neutrophil recruitment after myocardial infarction in rat

Hamid Soraya 1, Maryam Rameshrad 2, Aram Mokarizadeh 3, Alireza Garjani 2 *

Cited by CrossRef: 21

1- Ouyang M, Zhou D, Zhu Y, Zhang M, Li L. The inhibition of MyD88 and TRIF signaling serve equivalent roles in attenuating myocardial deterioration due to acute severe inflammation. Int J Mol Med. 2017; [Crossref]
2- Abedinzadeh N, Pedram B, Sadeghian Y, Nodushan S, Gilasgar M, Darvish M, Mokarizadeh A. RETRACTED ARTICLE: A histopathological analysis of the epidemiology of coronary atherosclerosis: an autopsy study. Diagn Pathol. 2015;10(1) [Crossref]
3- Varjabedian L, Bourji M, Pourafkari L, Nader N. Cardioprotection by Metformin: Beneficial Effects Beyond Glucose Reduction. Am J Cardiovasc Drugs. 2018;18(3):181 [Crossref]
4- Heidary Moghaddam R, Samimi Z, Asgary S, Mohammadi P, Hozeifi S, Hoseinzadeh‐Chahkandak F, Xu S, Farzaei M. Natural AMPK Activators in Cardiovascular Disease Prevention. Front Pharmacol. 2022;12 [Crossref]
5- Marzoog B, Vlasova T. Myocardiocyte autophagy in the context of myocardiocytes regeneration: a potential novel therapeutic strategy. Egypt J Med Hum Genet. 2022;23(1) [Crossref]
6- Malaekeh-Nikouei A, Shokri-Naei S, Karbasforoushan S, Bahari H, Baradaran Rahimi V, Heidari R, Askari V. Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins. Biomedicine & Pharmacotherapy. 2023;165:115263 [Crossref]
7- Dalan R. Metformin, neutrophils and COVID-19 infection. Diabetes Research and Clinical Practice. 2020;164:108230 [Crossref]
8- Liu G, Wu K, Zhang L, Dai J, Huang W, Lin L, Ge P, Luo F, Lei H. Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK. International Immunopharmacology. 2017;47:166 [Crossref]
9- Ling S, Xu J, Daiber A. NETosis as a Pathogenic Factor for Heart Failure. Oxidative Medicine and Cellular Longevity. 2021;2021:1 [Crossref]
10- Fei Q, Ma H, Zou J, Wang W, Zhu L, Deng H, Meng M, Tan S, Zhang H, Xiao X, Wang N, Wang K. Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages. Journal of Molecular and Cellular Cardiology. 2020;145:1 [Crossref]
11- Shafqat A, Abdul Rab S, Ammar O, Al Salameh S, Alkhudairi A, Kashir J, Alkattan K, Yaqinuddin A. Emerging role of neutrophil extracellular traps in the complications of diabetes mellitus. Front Med. 2022;9 [Crossref]
12- Ursini F, Grembiale R, D’Antona L, Gallo E, D’Angelo S, Citraro R, Visca P, Olivieri I, De Sarro G, Perrotti N, Russo E. Oral Metformin Ameliorates Bleomycin-Induced Skin Fibrosis. Journal of Investigative Dermatology. 2016;136(9):1892 [Crossref]
13- Bolívar S, Noriega L, Ortega S, Osorio E, Rosales W, Mendoza X, Mendoza-Torres E. Novel Targets of Metformin in Cardioprotection: Beyond the Effects Mediated by AMPK. CPD. 2021;27(1):80 [Crossref]
14- Wang J, Li Z, Gao L, Qi Y, Zhu H, Qin X. The regulation effect of AMPK in immune related diseases. Sci China Life Sci. 2018;61(5):523 [Crossref]
15- Zhang D, Tang Q, Zheng G, Wang C, Zhou Y, Wu Y, Xuan J, Tian N, Wang X, Wu Y, Xu H, Zhang X. Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP‐9 expression but not direct TJ proteins expression regulation. J Cellular Molecular Medi. 2017;21(12):3322 [Crossref]
16- Feng Y, Zhang Y, Xiao H. AMPK and cardiac remodelling. Sci China Life Sci. 2018;61(1):14 [Crossref]
17- Packer M. Drugs That Ameliorate Epicardial Adipose Tissue Inflammation May Have Discordant Effects in Heart Failure With a Preserved Ejection Fraction as Compared With a Reduced Ejection Fraction. Journal of Cardiac Failure. 2019;25(12):986 [Crossref]
18- Fung C, Wan E, Wong C, Jiao F, Chan A. Effect of metformin monotherapy on cardiovascular diseases and mortality: a retrospective cohort study on Chinese type 2 diabetes mellitus patients. Cardiovasc Diabetol. 2015;14(1) [Crossref]
19- Kamyshnyi O, Matskevych V, Lenchuk T, Strilbytska O, Storey K, Lushchak O. Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential. Biomedicine & Pharmacotherapy. 2021;144:112230 [Crossref]
20- Al-kuraishy H, Al-Gareeb A, Alblihed M, Cruz-Martins N, Batiha G. COVID-19 and Risk of Acute Ischemic Stroke and Acute Lung Injury in Patients With Type II Diabetes Mellitus: The Anti-inflammatory Role of Metformin. Front Med. 2021;8 [Crossref]
21- Korotina M, Pochinka I, Strongin L. Use of metformin in patients with type 2 diabetes and acute myocardial infarction: safety and impact on glycemic control. Probl Endokrinol (Mosk). 2023;69(1):28 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
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