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Bioimpacts. 2011;1(4): 241-244.
doi: 10.5681/bi.2011.035
PMID: 23678435
PMCID: PMC3648968
Scopus ID: 84876743341
  Abstract View: 2242
  PDF Download: 1164

Original Research

Free Radical Scavenging Potential and Essential Oil Composition of the Dorema glabrum Fisch. C.A. Mey Roots from Iran

Solmaz Asnaashari 1, Elmira Dadizadeh 2, Amir Hossein Talebpour 3, Morteza Eskandani 2, Hossein Nazemiyeh 2*

1 Department Drug Applied Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
2 Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3 East Azerbaijan Research Center for Agriculture and Natural Resources, Tabriz, Iran
*Corresponding Author: Email: nazemiyehh@yahoo.com

Abstract

Introduction: Dorema glabrum is an endangered species that grow in Transcaucasia and North West of Iran. The plant has extensive uses e.g. as an herbal remedy or food additive in these regions.  The chemical composition of hydrodistilled oil of D. glabrum growing in Iran was analyzed by GC-MS for the first time. Methods: The essential oil of air-dried roots was obtained by hydrodistillation using a Clevenger type apparatus. The oil was subjected to GC-MS analysis and its free radical scavenging properties were determined by DPPH method. Results: Thirty four constituents were identified that represented 81.6% of the total oil. The main compounds were delta-Cadinene (12.77%), beta-bisabolene (7.48%), alpha-Fenchyl acetate (6.32%), Copaene (5.68%) and Cubenol (5.42%). The essential oil had weak free radical scavenging properties with the RC50 value of 2.24 mg/mL. Conclusion: Present work is the first report on chemical composition of the essential oil obtained from D. glabrum roots. GC-MS Analysis showed that the oil was rich in sesquiterpenes. It deems that weak free radical scavenging activity of the oil is due to absence of potent antioxidant compounds.
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Submitted: 10 Oct 2011
Revision: 25 Nov 2011
Accepted: 15 Dec 2011
ePublished: 05 Jan 2012
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