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Original Research

1. Kinetic and thermodynamic study of beta-Boswellic acid interaction with Tau protein investigated by surface plasmon resonance and molecular modeling methods
Hossein Haghaei ORCID, Seyed Rafie Aref Hosseini ORCID, Somaieh Soltani, Farzaneh Fathi ORCID, Farzad Mokhtari ORCID, Saeed Karima ORCID, Mohammad-Reza Rashidi* ORCID
Bioimpacts. 2020;10(1): 17-25. doi: 10.15171/bi.2020.03
PMCID: PMC6977593     PMID: 31988853     Scopus ID: 85078964902    
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Investigation of the kinetic and thermodynamic interaction of Beta-Boswellic acid with Tau protein by surface plasmon resonance and molecular modeling methods revealed that hydrophobic bonding is the main force involved in the interaction.
Original Article

2. Mode of binding, kinetic and thermodynamic properties of a lipid-like drug (Fingolimod) interacting with Human Serum Albumin
Samira Gholizadeh ORCID, Hossein Haghaei, Hosna Karami, Somaieh Soltani* ORCID, Mostafa Zakariazadeh, Javad Shokri
Bioimpacts. 2023;13(2): 109-121. doi: 10.34172/bi.2022.23383
PMCID: PMC10182447     PMID: 37193080     Scopus ID: 85152094869    
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Interaction of the Fingolimod with HSA was studied using multi-spectroscopic and molecular modeling methods. Fingolimod binds to the binding site II of HSA via hydrogen bonds and Van der Walls forces. The binding is enthalpy driven. Fingolimod interaction with HSA leads to the conformational change of HSA.

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
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