Tabriz University of Medical Sciences BioImpacts 2228-5652 2 4 2012 12 21 Annual Fasting; the Early Calories Restriction for Cancer Prevention 213 215 10.5681/bi.2012.028 EN Solat Eslami Zahra Barzgari Negar Saliani Nazli Saeedi Abolfazl Barzegari Journal Article 10.5681/bi.2012.028 2012 06 06 Essentially, people’s diet and nutritional status has been changed substantially worldwide and several lines of evidence suggest that these changes are to the detriment of their health. Additionally, it has been well documented that unhealthy diet especially the fast foods, untraditional foods or bad-eating-habits influence the human gut microbiome. The gut microbiota shapes immune responses during human life and affects his/her metabolomic profiles. Furthermore, many studies highlight the molecular pathways that mediate host and symbiont interactions that regulate proper immune function and prevention of cancer in the body. Intriguingly, if cancer forms in a human body due to the weakness of immune system in detriment of microbiome, the removal of cancer stem cells can be carried out through early Calories Restriction with Annual Fasting (AF) before tumor development or progress. Besides, fasting can balance the gut microbiome for enhancement of immune system against cancer formation.