Tabriz University of Medical Sciences BioImpacts 2228-5652 6 2 2016 06 30 Infection-resistant MRI-visible scaffolds for tissue engineering applications 111 115 10.15171/bi.2016.16 EN Morteza Mahmoudi Mingming Zhao Yuka Matsuura Sophie Laurent Phillip C. Yang Daniel Bernstein Pilar Ruiz-Lozano Vahid Serpooshan Journal Article 10.15171/bi.2016.16 2016 07 31 2016 07 12 Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium.By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of biomaterial-based regenerative therapies.