Tabriz University of Medical Sciences BioImpacts 2228-5652 11 4 2021 07 30 Relationship between endocrine disruptors and obesity with a focus on bisphenol A: a narrative review 289 300 10.34172/bi.2021.33 EN Sofiane Boudalia https://orcid.org/0000-0002-7729-185X Aissam Bousbia https://orcid.org/0000-0002-0514-4834 Boualem Boumaaza Malha Oudir Marie Chantal Canivenc Lavier Journal Article 10.34172/bi.2021.33 2019 08 10 2020 05 10 Introduction: Scientific data suggest that early exposure to endocrine-disrupting chemicals (EDCs) affect -repro, -neuro, -metabolic systems, to which are added other notions such as mixtures, window and duration of exposure, trans-generational effects, and epigenetic mechanisms. Methods: In the present narrative review, we studied the relationship between exposure to EDCs with the appearance and development of obesity. Results: Exposure to EDCs like Bisphenol A during the early stages of development has been shown to lead to weight gain and obesity. EDCs can interfere with endocrine signaling, affect adipocytes differentiation and endocrine function and disrupt metabolic processes, especially if exposure occurs at very low doses, in the mixture, during early development stages for several generations. Conclusion: Exposure to EDCs is positively associated with obesity development. Moreover, the use of integrative approaches which mimicking environmental conditions are necessary and recommended to evaluate EDCs' effects in future studies.