Tabriz University of Medical Sciences BioImpacts 2228-5652 10 1 2020 01 01 Therapeutic impacts of enzyme-responsive smart nanobiosystems 1 4 10.15171/bi.2020.01 EN Marziyeh Fathi https://orcid.org/0000-0001-5710-6365 Azam Safary https://orcid.org/0000-0002-8997-2003 Jaleh Barar https://orcid.org/0000-0002-0105-919X EDITORIAL 10.15171/bi.2020.01 2019 09 11 2019 11 11 An important arena of the sophisticated nanosystems (NSs) is the combination of the responsive features of NSs with the biocatalytic properties of enzymes. The development of such smart drug delivery systems (DDSs) has seminal effectiveness in targeting, imaging, and monitoring of cancer. These NSs can exhibit site-specific delivery of the toxic cargo in response to the endogenous/exogenous stimuli. Enzyme responsive/targeted DDSs display enhanced accumulation of cargo molecules in the tumor microenvironment (TME) with a spatiotemporal controlled-release behavior. Based on the unique features of enzyme responsive/targeted DDSs, they offer incredible promise in overcoming some limitations of the currently used conventional DDSs. Taken all, targeting TME with the enzyme-responsive targeted DDSs may lead to versatile clinical outcomes in various malignancies.