Tabriz University of Medical Sciences BioImpacts 2228-5652 12 3 2022 05 01 SARS-CoV-2 and probable lung cancer risk 291 292 10.34172/bi.2022.23266 EN Sajad Khiali https://orcid.org/0000-0002-2476-4430 Afra Rezagholizadeh https://orcid.org/0000-0001-9684-6198 Taher Entezari-Maleki https://orcid.org/0000-0003-3653-3653 Journal Article 10.34172/bi.2022.23266 2020 07 25 2020 11 02 The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global crisis with a growing number of mortalities and morbidities worldwide. Despite performing numerous researches, there are still considerable unrevealed details regarding the long-term complications and post-infection immunity of the coronavirus disease 2019 (COVID-19). Based on pathophysiological features, SARS-CoV-2 may act similarly as an oncovirus in the lung. This letter summarized three possible oncogenic mechanisms of SARS-CoV-2 that may be associated with lung cancer development.