Tabriz University of Medical Sciences BioImpacts 2228-5652 12 2 2022 02 06 Gut microbial signature and gut-lung axis: A possible role in the therapy of COVID-19 175 177 10.34172/bi.2021.42 EN Ata Mahmoodpoor https://orcid.org/0000-0002-4361-6230 Ali Shamekh Sarvin Sanaie https://orcid.org/0000-0003-2325-5631 Journal Article 10.34172/bi.2021.42 2020 08 08 2021 03 17 The impact of gut as the origin of different disorders has led to the "gut-origin concept" of diseases. The gut microbiome regulates host defenses against viral infections, thus dysbiosis can play a major role in triggering the cascade of inflammation and causing immune imbalances in COVID-19 patients. It appears that gut microbial signature in COVID-19 patients can be used as a potential diagnostic, therapeutic, and even a prognostic marker. Personalized nutrition therapy can be used by profiling the gut microbiota of individual patients and specialized probiotics/synbiotics to modify gut dysbiosis. Hence, improving overall immune responses can be recommended in these patients.