Tabriz University of Medical Sciences BioImpacts 2228-5652 12 3 2022 05 01 Opioid overdose, interventions, and challenges 179 181 10.34172/bi.2022.24093 EN Samaneh Alaei https://orcid.org/0000-0003-3484-9400 Hossein Omidian https://orcid.org/0000-0002-5637-8729 EDITORIAL 10.34172/bi.2022.24093 2021 09 20 2021 09 28 This short letter briefly reviews the significance of opioid overdose as well as the existing approaches to combat the epidemic. It also signifies the importance of naloxone, its commercially available dosage forms, and the unmet need for developing safe and effective naloxone dosage forms that can easily be administered in emergency settings.