Tabriz University of Medical Sciences BioImpacts 2228-5652 15 1 2025 01 19 Exploring the potential of tubulin-associated unit protein as a biomarker for schizophrenia 30813 30813 10.34172/bi.30813 EN Ali Reza Shafiee-Kandjani https://orcid.org/0000-0002-3045-2644 Ali Bazzaz Haghighat Talab Sara Farhang Dariush Shanehbandi Milad Asadi Ailar Nakhlband https://orcid.org/0000-0002-4883-6902 Journal Article 10.34172/bi.30813 2024 10 16 2025 11 01 Introduction: Schizophrenia is a chronic and debilitating psychiatric disease characterized by various causes and symptoms. The tau protein is recognized as a biomarker that plays a crucial role in neurocognitive and neurodegenerative diseases. Given the presence of cognitive symptoms in individuals with schizophrenia, the objective of this study was to measure to evaluate the diagnostic potential of measuring serum levels of total tau and phosphorylated tau in patients with schizophrenia. Methods: A total of 40 patients with schizophrenia who met the inclusion criteria were selected, along with 40 age- and sex-matched healthy individuals. Written consent was obtained from all participants, and blood samples were collected to measure the serum levels of total tau protein and phosphorylated tau. The obtained data were analyzed using appropriate statistical methods with SPSS 23 software. Results: There was no statistically significant disparity detected in the serum concentrations of total and phosphorylated tau protein when comparing individuals with schizophrenia to those without the disorder. Conclusion: Based on the results obtained, it can be concluded that total tau protein and phosphorylated tau cannot be considered as diagnostic biomarkers for schizophrenia. Furthermore, the findings of this study do not support the presence of neuroanalysis in schizophrenia.