Tabriz University of Medical Sciences BioImpacts 2228-5652 16 1 2026 01 04 Three-dimensional bioprinted hydrogels for the management of diabetic wounds: A review 32751 32751 10.34172/bi.32751 EN Piyali Khamkat https://orcid.org/0000-0002-9351-4347 Bramhajit Chatterjee Sourav Ghosh Bhupendra Prajapati Biswajit Basu Sudarshan SIngh https://orcid.org/0000-0002-7929-3322 Journal Article 10.34172/bi.32751 2025 08 30 2025 11 18 Globally, the prevalence of diabetes mellitus (DM), a chronic metabolic disease, is at its peak. Type 2 diabetes (T2D) is more common worldwide, which raises the risk of ulcers and chronic healing, or non-healing wounds. Overall 15% to 20% of people with diabetes develop diabetic foot ulcers (DFUs), which is a significant consequence. Managing and treatment of wounds require an advancement of novel healing therapies with the use of biological dressings. The development of DFU wound dressings and the biomanufacturing of composite 3D skin substitutes are examples of 3D bioprinting technology for enhancing therapeutic approaches. These approaches and challenges of bioprinting technology in wound healing of chronic DFUs are covered in this review. Moreover, the review highlights the selection of biomaterials, integration of biomimetic approaches, and the ability of 3D bioprinting to replicate native skin architecture. Despite significant advances, the review identifies critical gaps including limited vascularization in printed constructs, standardization issues, and scalability challenges that impede clinical translation. Emerging biotechnological tools and novel biomaterial developments are also discussed, emphasizing their potential to overcome these limitations and improve DFU wound management.