Tabriz University of Medical Sciences BioImpacts 2228-5652 16 1 2026 01 04 Nanostructured implants for enhanced integration and localized therapy 33489 33489 10.34172/bi.33489 EN Aditya Singh https://orcid.org/0000-0002-0398-6130 Shubhrat Maheshwari Anvi Patel Bhupendra G. Prajapati https://orcid.org/0000-0001-8242-4541 Ankush Mehta Kiran Dudhat Journal Article 10.34172/bi.33489 2026 02 01 2026 05 06 Nanoparticles have emerged as a promising strategy in dental implantology to enhance implant integration and therapeutic functionality. Nanostructured surface modifications enable precise control over implant topography and chemistry, leading to increased surface area, improved protein adsorption, and enhanced cellular adhesion, key factors for successful osseointegration. Various nanoparticle systems, including titanium dioxide (TiO₂), hydroxyapatite, and bioactive glass, have been extensively explored for surface modification and functional enhancement of dental implants. In addition to structural benefits, nanoparticles facilitate localized and controlled drug delivery, reducing infection risk, minimizing systemic side effects, and accelerating tissue healing. Despite these advancements, challenges such as long-term stability, biocompatibility, optimization of drug release kinetics, and potential toxicity remain critical barriers to clinical translation. Therefore, further research is required to ensure safe and effective application of nanoparticle-based dental implants in clinical practice.