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Bioimpacts. 2020;10(2): 65-72. doi: 10.34172/bi.2020.09
PMID: 32363150        PMCID: PMC7186545

Original Research

Lactobacillus plantarum induces apoptosis in gastric cancer cells via modulation of signaling pathways in Helicobacter pylori

Hadi Maleki-Kakelar 1 ORCID, Jaber Dehghani 1, Abolfazl Barzegari 1, Jaleh Barar 1,2 ORCID, Masoud Shirmohamadi 3, Javid Sadeghi 4, Yadollah Omidi 1,2 * ORCID

Cited by CrossRef: 13

1- Masheghati F, Asgharzadeh M, Jafari A, Masoudi N, Maleki-Kakelar H. The role of gut microbiota and probiotics in preventing, treating, and boosting the immune system in colorectal cancer. Life Sciences. 2024;344:122529 [Crossref]
2- Davoodvandi A, Fallahi F, Tamtaji O, Tajiknia V, Banikazemi Z, Fathizadeh H, Abbasi-Kolli M, Aschner M, Ghandali M, Sahebkar A, Taghizadeh M, Mirzaei H. An Update on the Effects of Probiotics on Gastrointestinal Cancers. Front Pharmacol. 2021;12 [Crossref]
3- Nikitina E, Orlova S, Ivanov S, Orlova A. Unknown Known: Lactobacillus plantarum. Yesterday, Today, Tomorrow. Medicinskij alfavit. 2021;(23):21 [Crossref]
4- Mukherjee A, Wanjari U, Bradu P, Murali R, Kannampuzha S, Loganathan T, C G, Prakash B.P A, Renu K, Dey A, Vellingiri B, Valsala Gopalakrishnan A. The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis. Critical Reviews in Oncology/Hematology. 2022;176:103757 [Crossref]
5- Li Z, Liu J, Lu L, Wang L, Xu L, Guo Z, Dong Q. Overgrowth of Lactobacillus in gastric cancer. WJGO. 2021;13(9):1099 [Crossref]
6- Javid H, Karimi-Shahri M, Khorramdel M, Mashhad A, Tabrizi A, Sathyapalan T, Afshari A, Sahebkar A. Probiotics as an Adjuvant for Management of Gastrointestinal Cancers through their Anti-inflammatory Effects: A Mechanistic Review. CMC. 2023;30(4):390 [Crossref]
7- Kim S, Lee H, Choi W, Kang C, Kim G, Cho H. Anti-Tumor Effect of Heat-Killed Bifidobacterium bifidum on Human Gastric Cancer through Akt-p53-Dependent Mitochondrial Apoptosis in Xenograft Models. IJMS. 2022;23(17):9788 [Crossref]
8- Contino K, Cook K, Shiozawa Y. Bones and guts – Why the microbiome matters. Journal of Bone Oncology. 2024;44:100523 [Crossref]
9- Alizadeh S, Esmaeili A, Barar J, Omidi Y. Optogenetics: A new tool for cancer investigation and treatment. Bioimpacts. 2022;12(4):295 [Crossref]
10- Abouelela M, Helmy Y. Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives. Microorganisms. 2024;12(3):430 [Crossref]
11- Mohseni A, Casolaro V, Bermúdez-Humarán L, Keyvani H, Taghinezhad-S S. Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response. Gut Microbes. 2021;13(1) [Crossref]
12- Wajahat S. Role of microorganisms in the developmental, prognostic, and therapeutics of gastric cancer. Iranian Journal of Blood and Cancer. 2023;15(4):272 [Crossref]
13- Abedi A, Tafvizi F, Jafari P, Akbari N. The inhibition effects of Lentilactobacillus buchneri-derived membrane vesicles on AGS and HT-29 cancer cells by inducing cell apoptosis. Sci Rep. 2024;14(1) [Crossref]
14- He C, Peng C, Xu X, Li N, Ouyang Y, Zhu Y, Lu N. Probiotics mitigate Helicobacter pylori‐induced gastric inflammation and premalignant lesions in INS‐GAS mice with the modulation of gastrointestinal microbiota. Helicobacter. 2022;27(4) [Crossref]
15- Wang L, Li S, Fan H, Han M, Xie J, Du J, Peng F. Bifidobacterium lactis combined with Lactobacillus plantarum inhibit glioma growth in mice through modulating PI3K/AKT pathway and gut microbiota. Front Microbiol. 2022;13 [Crossref]
16- Hwang C, Lee N, Paik H. The Anti-Cancer Potential of Heat-Killed Lactobacillus brevis KU15176 upon AGS Cell Lines through Intrinsic Apoptosis Pathway. IJMS. 2022;23(8):4073 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge