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Bioimpacts. 2017;7(1): 5-12. doi: 10.15171/bi.2017.02
PMID: 28546948        PMCID: PMC5439390

Original Research

Liquigroud technique: a new concept for enhancing dissolution rate of glibenclamide by combination of liquisolid and co-grinding technologies

Leila Azharshekoufeh 1, Javad Shokri 1, Mohammad Barzegar-Jalali 1,2, Yousef Javadzadeh 1,3 *

Cited by CrossRef: 7


1- Thakkar H, Vasava D, Patel A, Dhande R. Formulation and evaluation of liquisolid compacts of itraconazole to enhance its oral bioavailability. Therapeutic Delivery. 2020;11(2):83 [Crossref]
2- Akhtar F, Akhtar S, Ashfaq S, Rehman I, Mirza A. UV Spectroscopic Method for Optimization and Determination of Glibenclamide in Bulk, Pharmaceutical Dosage Form and its Application for In Vitro Interaction Studies. J Anal Test. 2020;4(4):281 [Crossref]
3- Sabbaghi N, Dadfarnia S, Haji Shabani A, Farsadrooh M. Dispersive micro solid phase extraction of glibenclamide from plasma, urine, and wastewater using a magnetic molecularly imprinted polymer followed by its determination by a high-performance liquid chromatography-photodiode array detector. RSC Adv. 2024;14(19):13168 [Crossref]
4- Bonthagarala B, Dasari V, Kotra V. Solubility enhancement effect at absorption site on bioavailability of ritonavir using liquisolid technique. Therapeutic Delivery. 2019;10(5):295 [Crossref]
5- Nazem N, Shokri J, Nourani N, Zangi A, Lam M, Nokhodchi A, Javadzadeh Y. Combining Liquisolid and Co-grinding Techniques to Enhance the Dissolution Rate of Celecoxib. J Pharm Innov. 2023;18(1):300 [Crossref]
6- Molaei M, Osouli-Bostanabad K, Adibkia K, Shokri J, Asnaashari S, Javadzadeh Y. Enhancement of ketoconazole dissolution rate by the liquisolid technique. 2018;68(3):325 [Crossref]
7- Gupta K, Dakhole M, Jinnawar K, Umekar M. Strategies for improving hydrophobic drugs solubility and bioavailability. IJPCA. 2023;10(3):164 [Crossref]
8- Srivastava D, Fatima Z, Kaur C, Mishra A, Nashik S, Rizvi D, Prasad R. Glibenclamide–malonic acid cocrystal with an enhanced solubility and bioavailability. Drug Development and Industrial Pharmacy. 2022;48(8):417 [Crossref]
9- Rashad A, Louis D. An overview on liquisolid technique: its development and applications. Therapeutic Delivery. 2022;13(12):577 [Crossref]


As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge