Bioimpacts. 2016;6(2):111-115.
doi: 10.15171/bi.2016.16
PMID: 27525229
PMCID: PMC4981249
Scopus id: 84983548259
  Abstract View: 1441
  PDF Download: 1137
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Short Communication

Infection-resistant MRI-visible scaffolds for tissue engineering applications

Morteza Mahmoudi 1,2,3, Mingming Zhao 4, Yuka Matsuura 2, Sophie Laurent 5,6, Phillip C. Yang 1,2, Daniel Bernstein 1,4, Pilar Ruiz-Lozano 1,4 * , Vahid Serpooshan 1,4 *

1 Stanford Cardiovascular Institute, Stanford, CA 94305, USA
2 Division of Cardiovascular Medicine, Stanford University, 300 Pasteur Dr., Stanford, CA 94305, USA
3 Nanotechnology Research Center and Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran
4 Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305, USA
5 Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, B-7000 Mons, Belgium
6 CMMI - Center for Microscopy and Molecular Imaging, Avenue A. Bolland, 8 B-6041 Gosselies, Belgium

Abstract

Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium.By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of biomaterial-based regenerative therapies.
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Submitted: 31 Jul 2016
Accepted: 12 Jul 2016
First published online: 15 Jul 2016
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