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Editorial
Yadollah Omidi ORCID, Abass Alavi* ORCID
BioImpacts. 2021;11(1): 1-4. doi: 10.34172/bi.2021.01
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Mohammad Rafi (Persian: محمد رفیع ) obtained his PhD from University of Montpellier, France, in 1970. Investigating lysosomal storage diseases, he focused on gene therapy of neurodegenerative disorders using globoid cell leukodystrophy (Krabbe disease) animal models. With successful AAVrh10-mediated therapy in animal models, his research is moving towards human clinical trials.
Original Research
Roya Dolatkhah ORCID, Saeed Dastgiri ORCID, Amir Taher Eftekhar Sadat, Faris Farassati, Marzieh Nezamdoust, Mohammad Hossein Somi* ORCID
BioImpacts. 2021;11(1): 5-14. doi: 10.34172/bi.2021.02
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Graphical Abstract
It has been suggested that the pattern of specific mutation including KRAS/NRAS/BRAF, are associated with different prognostic values and responses to anti-EGFR therapies.
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Graphical Abstract
LPS stimulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 by binding toTLR-4. iNOS produced enormous nitric oxide (NO) that stimulated COX-2 activity and prostaglandin E2 which further induced the production of pro-inflammatory cytokines leading to inflammation. ALK-F of A. vasica could attenuate iNOS and COX-2 gene expression reducing NO production.
Original Research
Malkiet Kaur ORCID, Manju Nagpal* ORCID, Manjinder Singh ORCID, Thakur Gurjeet Singh, Geeta Aggarwal ORCID, Gitika Arora Dhingra ORCID
BioImpacts. 2021;11(1): 23-31. doi: 10.34172/bi.2021.04
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Graphical Abstract
Cinnamon essential oil (CEO) is a volatile oil, obtained from Cinnamomum zeylanicum has become one of the most important natural oil due to its antimicrobial activity. CEO suffers from various limitations such as instability and skin irritation.
Original Research
Nurul Azmir Amir Hashim ORCID, Sharaniza Ab-Rahim, Wan Zurinah Wan Ngah, Sheila Nathan, Nurul Syakima Ab Mutalib, Ismail Sagap, A. Rahman A. Jamal, Musalmah Mazlan* ORCID
BioImpacts. 2021;11(1): 33-43. doi: 10.34172/bi.2021.05
Graphical Abstract
Global Serum from metabolomics on colorectal cancer (CRC) identified 11 differential metabolites which able to identify a new set of sample with 80% of accuracy. Pathway analysis shows purine, catecholamine and amino acid metabolism were altered in CRC patients.
Original Research
Seyedeh Sogol Pelaseyed ORCID, Hamid Reza Madaah Hosseini* ORCID, Zeinab Nokhbedehghan, Ali Samadikuchaksaraei
BioImpacts. 2021;11(1): 45-52. doi: 10.34172/bi.2021.06
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Graphical Abstract
Highly porous scaffolds consisting of poly (lactide-co-glycolide) containing TiO2 nanoparticles were fabricated via air-liquid foaming technique, which is a novel method and has more advantages by using no additives for nucleation compared to former ways.
Original Research
Farzaneh Barati ORCID, Ezat Asgarani* ORCID, Sara Gharavi, Mohammad Reza Soudi
BioImpacts. 2021;11(1): 53-57. doi: 10.34172/bi.2021.07
Graphical Abstract
Overexpression of phbC, the critical gene in PHB biosynthesis pathway, in R. eutropha PTCC 1615 had considerable effect on PHB accumulation.
Original Research
Muhammad H. Sultan ORCID, Wael A. Mahdi, Young M. Kwon* ORCID
BioImpacts. 2021;11(1): 59-64. doi: 10.34172/bi.2021.08
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Graphical Abstract
Pluronic F127 limits tissue enzymes to act on protamine on NPH insulin microcrystals to prevent acceleration of insulin release and help control blood glucose in STZ-induced diabetic rats uponsubcutaneous administration.
Original Research COVID-19
Mohammad Mostafa Pourseif ORCID, Sepideh Parvizpour, Behzad Jafari, Jaber Dehghani ORCID, Behrouz Naghili, Yadollah Omidi* ORCID
BioImpacts. 2021;11(1): 65-84. doi: 10.34172/bi.2021.11
Graphical Abstract
Immunodominant T-cell epitopes of SARS-CoV-2 spike protein with the highest population coverage were predicted by analyzing peptide binders and consensus rank (CR) score. Multi-method B-cell epitope prediction approach was used to find B-cell immunodominant regions of spike protein. Upon the high immune-potent regions of the antigen(s), self-amplifying mRNA and peptide-based vaccines were designed.


BioImpacts, as a peer-reviewed international journal, publishes all types of papers on bench-to-bedside translational aspects of pharmaceutical and biomedical sciences. As a "Publish Free" and "Access Free" journal, BioImpacts follows a constructive peer-review process with free editing service to benefit the scientific community worldwide.