Thematic Collection 

“Stem Cells and Extracellular Vesicles: Recent Progress and Translational Advances Toward Regenerative Medicine”

The rapid advance in stem cell biology and the deep understanding of extracellular vesicles (EVs)—especially exosomes, microvesicles, and other nano biocarriers—have opened new frontiers in regenerative medicine, immunomodulation, and therapeutic delivery. This thematic issue aims to highlight cutting-edge research, translational breakthroughs, and clinical perspectives on how stem cells and EV-based strategies can reshape the human medicine. Emphasis is placed on mechanistic insights, scalable manufacturing, safety evaluation, and clinical applicability across major disease domains.  The current thematic issue aims to provide a comprehensive synthesis of where the field stands today and where it is heading. The proposed articles can be categorized into mini-review and comprehensive review articles scoping the below topics as follows; 

1. Stem cell extracellular vesicles: mechanisms of action and therapeutic potential

2. Molecular cargo, signaling biomolecules, immunomodulatory and regenerative effects.

3. Clinical translation of stem cell-based therapies

4. Safety protocols, efficacy trends, regulatory challenges.

5. Disease modeling, cell replacement therapies, ethical considerations.

6. Extracellular vesicles as drug delivery nanoplatforms

7. Engineering EVs for targeted genetic, protein, and drug delivery.

Guest Editor

Reza Rahbarghazi is a scientist in clinical pathology and stem cell biology. He is a full professor and head of the Department of Applied Cell Sciences and dean of the Stem Cell and Regenerative Medicine (SCARM) Institute at Tabriz University of Medical Sciences (in Tabriz, Iran. His research focuses strongly on fundamental cell biology, especially on the mechanisms by which various stem cells can influence several underlying mechanisms and healing processes under various physiological and pathological conditions.