Mohammad Morad Farajollahi
1, Sepideh Hamzehlou
2, Ahmad Mehdipour
3, Ali Samadikuchaksaraei
1*1 Department of Medical Biotechnology, Cellular and Molecular Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Medical Biotechnology, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Tissue Engineering, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Proteins
constitute a group of key molecules with many applications in tissue
engineering. Use of proteins provided from natural sources has several
limitations which are overcome by the use of recombinant proteins. So
far, the recombinant forms of many proteins with tissue engineering
applications have been developed including structural proteins, growth
factors and cytokines. This technology has enabled the development of
specifically designed proteins such as growth factors with matrix
binding domains, and hybrid structural proteins with improved mechanical
properties. Recombinant proteins are produced either ex vivo or in vivo,
by local gene therapy protocols, and are of medical and economic
benefits. Due to the high applicability of recombinant proteins in
tissue engineering, it is recommended to include this platform as an
infrastructural element in any tissue engineering program.