Bioimpacts. 2015;5(4): 207-213.
doi: 10.15171/bi.2015.30
PMID: 26929925
PMCID: PMC4769791
Scopus ID: 84958175557
WOSID: 000372183500008
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Recent advances in immunosensor for narcotic drug detection

Sonu Gandhi 1*, Pankaj Suman 1, Ashok Kumar 2, Prince Sharma 3, Neena Capalash 3, C. Raman Suri 4

1 Amity Institute of Biotechnology, Amity University, Noida, India
2 CSIR- Institute of Genomics and Integrative Biology, Delhi, India
3 Department of Microbiology and Biotechnology, Panjab University, Chandigarh, India
4 CSIR- Institute of Microbial Technology, Chandigarh, India


Introduction: Immunosensor for illicit drugs have gained immense interest and have found several applications for drug abuse monitoring. This technology has offered a low cost detection of narcotics; thereby, providing a confirmatory platform to compliment the existing analytical methods.
Methods: In this minireview, we define the basic concept of transducer for immunosensor development that utilizes antibodies and low molecular mass hapten (opiate) molecules. 
Results: This article emphasizes on recent advances in immunoanalytical techniques for monitoring of opiate drugs. Our results demonstrate that high quality antibodies can be used for immunosensor development against target analyte with greater sensitivity, specificity and precision than other available analytical methods.
Conclusion: In this review we highlight the fundamentals of different transducer technologies and its applications for immunosensor development currently being developed in our laboratory using rapid screening via immunochromatographic kit, label free optical detection via enzyme, fluorescence, gold nanoparticles and carbon nanotubes based immunosensing for sensitive and specific monitoring of opiates.
Keywords: Transducer, Immunosensor, Narcotic drugs, Immunoanalytical techniques, Aptasensor
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Submitted: 13 Feb 2016
ePublished: 21 Jul 2016
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