Morteza Mahmoudi
1,2,3, Mingming Zhao
4, Yuka Matsuura
2, Sophie Laurent
5,6, Phillip C. Yang
1,2, Daniel Bernstein
1,4, Pilar Ruiz-Lozano
1,4*, Vahid Serpooshan
1,4*1 Stanford Cardiovascular Institute, Stanford, CA 94305, USA
2 Division of Cardiovascular Medicine, Stanford University, 300 Pasteur Dr., Stanford, CA 94305, USA
3 Nanotechnology Research Center and Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran
4 Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305, USA
5 Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, B-7000 Mons, Belgium
6 CMMI - Center for Microscopy and Molecular Imaging, Avenue A. Bolland, 8 B-6041 Gosselies, Belgium
Abstract
Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium.By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of biomaterial-based regenerative therapies.