Bioimpacts. 2016;6(2): 111-115.
doi: 10.15171/bi.2016.16
PMID: 27525229
PMCID: PMC4981249
Scopus ID: 84983548259
  Abstract View: 3078
  PDF Download: 2131
  Full Text View: 1544

Short Communication

Infection-resistant MRI-visible scaffolds for tissue engineering applications

Morteza Mahmoudi 1,2,3, Mingming Zhao 4, Yuka Matsuura 2, Sophie Laurent 5,6, Phillip C. Yang 1,2, Daniel Bernstein 1,4, Pilar Ruiz-Lozano 1,4*, Vahid Serpooshan 1,4*

1 Stanford Cardiovascular Institute, Stanford, CA 94305, USA
2 Division of Cardiovascular Medicine, Stanford University, 300 Pasteur Dr., Stanford, CA 94305, USA
3 Nanotechnology Research Center and Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran
4 Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305, USA
5 Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, B-7000 Mons, Belgium
6 CMMI - Center for Microscopy and Molecular Imaging, Avenue A. Bolland, 8 B-6041 Gosselies, Belgium


Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium.By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of biomaterial-based regenerative therapies.
Keywords: Antibacterial properties, Collagen scaffold, Magnetic resonance imaging, SPION, Superparamagnetic iron oxide nanoparticles, Tissue engineering
First Name
Last Name
Email Address
Security code

Abstract View: 3078

Your browser does not support the canvas element.

PDF Download: 2131

Your browser does not support the canvas element.

Full Text View: 1544

Your browser does not support the canvas element.

Submitted: 31 Jul 2016
Accepted: 12 Jul 2016
ePublished: 15 Jul 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)