Bioimpacts. 2012;2(2): 71-81.
doi: 10.5681/bi.2012.011
PMID: 23678444
PMCID: PMC3648923
Scopus ID: 84876742237
  Abstract View: 2162
  PDF Download: 1566


Nanocapsules: the weapons for novel drug delivery systems.

Pavankumar Kothamasu 1*, Hemanth Kanumur 2, Niranjan Ravur 2, Chiranjeevi Maddu 1, Radhika Parasuramrajam 2, Sivakumar Thangavel 1

1 Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Tamilnadu, India
2 Department of Pharmaceutics, Nandha College of Pharmacy and Research Institute, Tamilnadu, India


Introduction: Nanocapsules, existing in miniscule size, range from 10 nm to 1000 nm. They consist of a liquid/solid core in which the drug is placed into a cavity, which is surrounded by a distinctive polymer membrane made up of natural or synthetic polymers. They have attracted great interest, because of the protective coating, which are usually pyrophoric and easily oxidized and delay the release of active ingredients.
Methods: Various technical approaches are utilized for obtaining the nanocapsules; however, the methods of interfacial polymerization for monomer and the nano-deposition for preformed polymer are chiefly preferred. Most important characteristics in their preparation is particle size and size distribution which can be evaluated by using various techniques like X-ray diffraction, scanning electron microscopy, transmission electron microscopy, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, superconducting quantum interference device, multi angle laser light scattering and other spectroscopic techniques.
Results: Nanocapsules possessing extremely high reproducibility have a broad range of life science applications. They may be applied in agrochemicals, genetic engineering, cosmetics, cleansing products, wastewater treatments, adhesive component applications, strategic delivery of the drug in tumors, nanocapsule bandages to fight infection, in radiotherapy and as liposomal nanocapsules in food science and agriculture. In addition, they can act as self-healing materials.
Conclusion: The enhanced delivery of bioactive molecules through the targeted delivery by means of a nanocapsule opens numerous challenges and opportunities for the research and future development of novel improved therapies.

Keywords: Nanocapsules, Encapsulation, Drug delivery system, Targeted drug release, Nanocapsule bandages, Life science applications
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Submitted: 24 Aug 2011
Revision: 31 Mar 2012
Accepted: 04 Apr 2012
ePublished: 05 Apr 2012
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