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Bioimpacts. 2017;7(4): 209-217.
doi: 10.15171/bi.2017.25
PMID: 29435428
PMCID: PMC5801532
Scopus ID: 85040670486
WOSID: 000423937100002
  Abstract View: 1661
  PDF Download: 590
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Methodology

Study-based registers of randomized controlled trials: Starting a systematic review with data extraction or meta-analysis

Farhad Shokraneh 1 * ORCID logo, Clive Elliott Adams 1 ORCID logo

1 Cochrane Schizophrenia Group, the Institute of Mental Health, a partnership between the University of Nottingham and Nottinghamshire Healthcare NHS Trust, Nottingham, United Kingdom

Abstract

Introduction: Despite years of use of study-based registers for storing reports of randomized controlled trials (RCTs), the methodology used in developing such registers/databases has not been documented. Such registers are integral to the process of scientific reviewing. We document and discuss methodological aspects of the development and use of study-based registers. Although the content is focused on the study-based register of randomized/controlled clinical trials, this work applies to developers of databases of all sorts of studies related to the human, animals, cells, genes, and molecules.
Methods: We describe necessity, rationale, and steps for the development, utilization and maintenance of study-based registers as well as the challenges and gains for the organizations supporting systematic reviews of the published and unpublished literature.
Conclusion: The ultimate goal of having a study-based register is to facilitate efficient production of systematic reviews providing rapid, yet accurate, evidence for the decision-makers. We argue that moving towards study-based registers is an inevitable welcome direction and that infrastructures are ready for such movement.
Keywords: Cochrane collaboration, Randomized controlled trials as topic, Reference-based register, Study-based register, Systematic reviews
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Submitted: 25 May 2017
Revision: 11 Sep 2017
Accepted: 16 Sep 2017
ePublished: 17 Sep 2017
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