Bioimpacts. 2011;1(3): 145-147.
doi: 10.5681/bi.2011.019
PMID: 23678419
PMCID: PMC3648960
Scopus ID: 84865491877
  Abstract View: 1875
  PDF Download: 1091


Smart Multifunctional Theranostics: Simultaneous Diagnosis and Therapy of Cancer

Yadollah Omidi 1,2* ORCID logo

1 Ovarian Cancer Research Center, School of Medicine, University of Pennsylvania, Philadelphia, USA
2 Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran


Clinical applications of advanced nanomedicines such as PEGylated liposomal doxorubicin and paclitaxel-albumin bioconjugates have significantly improved the cancer treatment strategies. However, these pharmaceuticals lack early detection and single cell tracking capabilities. Thus, engineering of smart multifunctional theranostics appear to be our next stepfor simultaneous diagnosis and therapy of cancer. Clinical translation of multifunctional theranostics appears to be dependent upon specificity of cancer biomarkers, biocompatibility of components used for formulation, and advancement of bioconjugation techniques. While many cancer biomarker candidates often fail to be used for clinical diagnosis/therapy because of their nonspecific functional expression in normal tissues, biocompatibility of materials used for bioconjugationalso needs to be approved.  All these issues need to be fully addressed prior to the translation of smart multifunctional cancer theranostics.
Keywords: Cancer Nanomedicines, Cancer Targeting, Cancer Theranostics, Cancer Therapy
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Submitted: 10 Sep 2011
Accepted: 15 Sep 2011
ePublished: 30 Sep 2011
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