Bioimpacts. 2012;2(4): 173-174.
doi: 10.5681/bi.2012.029
PMID: 23678457
PMCID: PMC3648940
Scopus ID: 84876813203
  Abstract View: 1696
  PDF Download: 1485


Pharmaceutical Nanoparticles and the Mucin Biopolymer Barrier

Ghaith Aljayyoussi, Muthanna Abdulkarim, Peter Griffiths, Mark Gumbleton*


Mucus in the gastrointestinal tract remains a tenacious barrier that restricts the passage of many orally administered compounds into the GIT’s epithelial layer and consequently into the systemic circulation. This results in significant decreases in the oral bioavailability of many therapeutic molecules. Nanoparticles offer an avenue to surpass this mucus barrier. They can be used as drug carriers to improve the bioavailability of many compounds that are restricted by mucus. Nanoparticles achieve penetration of the mucus barrier through a multitude of properties that they possess as their size, charge density, and surface functional groups which can all be tailored to achieve optimal penetration of the thick and fibrous mucus barrier. This article offers a quick review about the use of nanoparticles as drug carriers to increase mucus penetration in the gastro intestinal tract.
Keywords: Nanoparticles, Mucus, Mucin
First Name
Last Name
Email Address
Security code

Abstract View: 1697

Your browser does not support the canvas element.

PDF Download: 1485

Your browser does not support the canvas element.

Submitted: 08 Nov 2012
Revision: 20 Nov 2012
ePublished: 22 Nov 2012
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)