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Bioimpacts. 2013;3(2): 49-51.
doi: 10.5681/bi.2013.014
PMID: 23878787
PMCID: PMC3713870
Scopus ID: 84881521871
  Abstract View: 1721
  PDF Download: 967

Editorial

Targeted Gene Therapy of Cancer: Second Amendment toward Holistic Therapy

Jaleh Barar ORCID logo, Yadollah Omidi* ORCID logo
*Corresponding Author: Email: yomidi@yahoo.com

Abstract

It seems solid tumors are developing smart organs with specialized cells creating specified bio-territory, the so called “tumor microenvironment (TME)”, in which there is reciprocal crosstalk among cancer cells, immune system cells and stromal cells. TME as an intricate milieu also consists of cancer stem cells (CSCs) that can resist against chemotherapies. In solid tumors, metabolism and vascularization appears to be aberrant and tumor interstitial fluid (TIF) functions as physiologic barrier. Thus, chemotherapy, immunotherapy and gene therapy often fail to provide cogent clinical outcomes. It looms that it is the time to accept the fact that initiation of cancer could be generation of another form of life that involves a cluster of thousands of genes, while we have failed to observe all aspects of it. Hence, the current treatment modalities need to be re-visited to cover all key aspects of disease using combination therapy based on the condition of patients. Perhaps personalized cluster of genes need to be simultaneously targeted.
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Submitted: 29 Jan 2013
ePublished: 07 Feb 2013
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