Solat Eslami, Zahra Barzgari, Negar Saliani, Nazli Saeedi, Abolfazl Barzegari*
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Jaleh Barar  , Yadollah Omidi*
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Ibrahim Torktaz*, Faezeh Mohamadhashem, Abolghasem Esmaeili, Mohaddeseh Behjati, Sara Sharifzadeh
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Zohreh Ebrahimnezhad, Nosratollah Zarghami*, Manoutchehr Keyhani, Soumaye Amirsaadat, Abolfazl Akbarzadeh, Mohammad Rahmati, Zohreh Mohammad Taheri, Kazem Nejati-Koshki
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Umamaheswaran Gurusamy*, Steven Aibor Dkhar, Arun Kumar Annan Sudarsan, Katiboina Srinivasa Rao, Dharanipragada Kadambari, Chandrasekaran Adithan
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Jaleh Barar* , Yadollah Omidi*
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Yalda RahbarSaadat, Nazli Saeidi, Sepideh Zununi Vahed, Abolfazl Barzegari*, Jaleh Barar
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Yadollah Omidi , Jaleh Barar*
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Omid Mashinchian, Mohammad Johari-Ahar, Behnaz Ghaemi, Mohammad Rashidi, Jaleh Barar* , Yadollah Omidi*
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Jaleh Barar* , Yadollah Omidi*
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Mohammad A. Rafi, Yadollah Omidi*
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Jalil Pirayesh Islamian*, Mohsen Mohammadi, Behzad Baradaran, Alireza Farajollahi, Seyed Mahmoud Reza Aghamiri, Mohammad Asghari Jafarabadi, Haadi Karami, Amir Monfaredan, Dariuosh Shanehbandi
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Babak Nami* , Armin Ghasemi-Dizgah, Akbar Vaseghi
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Mohammad-Hossein Biglu*, Parvaneh Abotalebi, Mostafa Ghavami*
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Masoud Asadi-Khiavi, Hossein Hamzeiy*, Sajjad Khani, Ailar Nakhlband, Jaleh Barar*
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Yadollah Omidi*
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Yadollah Omidi*
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Jaleh Barar*
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Mohammad Pourhassan-Moghaddam, Behrouz Farhadi, Kazem Nejati-Koshki*
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Jaleh Barar , Yadollah Omidi*
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Abbas Asoudeh-Fard, Abolfazl Barzegari, Alireza Dehnad, Sepideh Bastani, Asal Golchin, Yadollah Omidi*
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Abolghasem Jouyban*, Djavanshir Djozan, Parastou Mohammadandashti, Aliakbar Alizadeh-Nabil, Hooshangh Ghorbanpour, Maryam Khoubnasabjafari, Mohammad Mohammadzadeh
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Mohammad Reza Asgharzadeh, Jaleh Barar , Mohammad M. Pourseif, Morteza Eskandani, Mojtaba Jafari Niya, Mohammad Reza Mashayekhi, Yadollah Omidi*
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Muhammad Nuh Musa, Sheba Rani David* , Ihsan Nazurah Zulkipli , Abdul Hanif Mahadi, Srikumar Chakravarthi, Rajan Rajabalaya*
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Hassan Moghtaderi, Houri Sepehri*, Ladan Delphi, Farnoosh Attari
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Marziyeh Fathi, Parham Sahandi Zangabad, Sima Majidi, Jaleh Barar, Hamid Erfan-Niya, Yadollah Omidi*
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Ayuob Aghanejad, Hiwa Babamiri, Khosro Adibkia, Jaleh Barar , Yadollah Omidi*
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Ananda Mookerjee, Michele Graciotti, Lana E. Kandalaft*
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Sepideh Parvizpour, Jafar Razmara, Yadollah Omidi*
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Sepideh Parvizpour, Jafar Razmara, Mohammad M. Pourseif, Yadollah Omidi*
Using
immunoinformatic tools, a multi-epitope peptide vaccine (consisting of CD8+cytotoxic T lymphocytes epitopes, helper epitopes and
adjuvant) was designed to combat the triple-negative breast cancer. The vaccine
showed acceptable immunogenicity and potential to stimulate both cellular and
humoral immune responses.
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Somayeh Vandghanooni, Morteza Eskandani, Jaleh Barar , Yadollah Omidi*
Aptamers (Aps) are short single-strand nucleic acids, which can be used as the therapeutic and targeting agent in advanced drug delivery systems. Conjugation of Aps with other entities (siRNA, toxins, drugs, DNAzyme/Ribozymes) provides advanced multifunctional nanosystems for cancer therapy.
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Mohammad Reza Asgharzadeh, Mohammad M. Pourseif, Jaleh Barar , Morteza Eskandani, Mojtaba Jafari Niya, Mohammad Reza Mashayekhi, Yadollah Omidi*
Increased expression of TSGA10 associated with the reduced metastasis in the MDA-MB-231 cells. TSGA10 showed interaction with HIF-1α with high affinity. TSGA10 expression is altered under the hypoxia, indicating its potential as a bio-target for cancer therapy.
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Nastran Hashemzadeh, Khosro Adibkia , Jaleh Barar*
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Mostafa Akbarzadeh Khiavi , Azam Safary , Mohammad Hossein Somi*
Colorectal cancer (CRC) as a malignancy shows high mortality rate worldwide because of metastasis and drug resistance. Targeted multimodal nanosystems (NSs) can be developed and used against CRC with much better clinical outcomes.
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Hadi Maleki-Kakelar , Jaber Dehghani, Abolfazl Barzegari, Jaleh Barar , Masoud Shirmohamadi, Javid Sadeghi, Yadollah Omidi*
Based on in vitro experiments, the anti-cancer effect of the locally isolated L. plantarum was validated through some signaling pathways, including PTEN, Bax, TLR4, and AKT genes.
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Mostafa Akbarzadeh Khiavi , Azam Safary , Jaleh Barar , Hamed Farzi-Khajeh, Abolfazl Barzegari, Rahimeh Mousavi, Mohammad Hossein Somi* , Yadollah Omidi*
The current study introduces an efficient ROS-responsive enzyme-based nanobiosystem and its biological impact in colon cancer therapy. Based on physicochemical properties, AuNPs-PEG-RNase A effectively induced apoptosis in SW-480 colon cancer cells and resulted in a significant reduction in cancer cell viability.
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Mitra Dolatkhah, Yadollah Omidi*
Dr. Yadollah Omidi (Pharm.D., Ph.D.) is a Professor of Pharmaceutical Sciences at TUOMS Faculty of Pharmacy, working on advanced multifunctional nanobiosystems. He has worked at Cardiff University and University of Pennsylvania. He has published over 210 papers and 18 book chapters, supervised and mentored over 100 graduate/postgraduate students/researchers.
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Mitra Moeinzadeh , Babak Kheirkhah* , Kumarss Amini , Ali Pouryasin
High prevalence of HPV- 53 and HPV-16 detected among participants with normal cytology can be considered as a tip-off development of cervical cancer among Iranian women.
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Siamak Alizadeh, Abolfazl Barzegari, Abolghasem Esmaeili*, Yadollah Omidi*
E. coli Nissle 1917 (EcN) is proposed as an appropriate light-activated vehicle for delivery of anticancer agents to the cancer cells/tissues such colorectal cancer.
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Roya Dolatkhah , Saeed Dastgiri , Amir Taher Eftekhar Sadat, Faris Farassati, Marzieh Nezamdoust, Mohammad Hossein Somi*
It has been suggested that the pattern of specific mutation including KRAS/NRAS/BRAF, are associated with different prognostic values and responses to anti-EGFR therapies.
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Amin Khodaei , Mohammad-Reza Feizi-Derakhshi* , Behzad Mozaffari-Tazehkand
In this research, cancer data are analyzed in the form of DNA in terms of nucleotide sequences. A hybrid machine learning and statistical approach was used for classification of genomic sequences.
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Nurul Azmir Amir Hashim , Sharaniza Ab-Rahim, Wan Zurinah Wan Ngah, Sheila Nathan, Nurul Syakima Ab Mutalib, Ismail Sagap, A. Rahman A. Jamal, Musalmah Mazlan*
Global Serum from metabolomics on colorectal cancer (CRC) identified 11 differential metabolites which able to identify a new set of sample with 80% of accuracy. Pathway analysis shows purine, catecholamine and amino acid metabolism were altered in CRC patients.
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Hazwani Mohd Yusof , Sharaniza Ab-Rahim, Wan Zurinah Wan Ngah, Sheila Nathan, A Rahman A Jamal, Musalmah Mazlan*
This study highlights the differential metabolite profiling in CRC cell lines corresponding to different stages.
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Ainaz Mihanfar, Bahman Yousefi, Saber Ghazizadeh Darband, Shirin Sadighparvar, Mojtaba Kaviani, Maryam Majidinia*
Treatment of SW-480 cancer cell lines with a combination of 5-FU and melatonin results in the increment in the sensitivity of cancer cells to 5-FU through downregulation of XIAP and survivin, as well as modulation of oxidative stress.
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Fatemeh Abedi Jafari , Asghar Abdoli* , Reza Pilehchian, Neda Soleimani, Seyed Masoud Hosseini
The experiment concluded that the C. novyi nontoxic might be a suitable and safe candidate, a novel therapeutic approach to encounter such hypoxic regions in the center of tumors
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Najme Dehghani , Farzaneh Tafvizi* , Parvaneh Jafari
The supernatant of probiotic L. rhamnosus has a great potential to inhibit the proliferation of HT-29 cells and the induction of apoptosis.
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Ysrafil Ysrafil* , Indwiani Astuti
Chitosan nanoparticle antimiRNA-324-5p could inhibit ovarian cancer proliferation by reduce endogenous miRNA-324-5p to lead restoration of MEN1 and generates repression of GLI1 expression.
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Siamak Alizadeh , Abolghasem Esmaeili, Jaleh Barar , Yadollah Omidi*
Optogenetics approaches can provide us with outstanding tool to extend our understanding of how cells perceive, respond, and behave in meeting with complex signals, particularly in terms of cancer evasion from the anticancer immune system functions.
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Amir Shakouri , Houman Kahroba, Hamed Hamishekar, Jalal Abdolalizadeh*
In the first stage of the procedure, medical leech saliva was extracted and for encapsulating these proteins, liposome technique was applied. Continually, nano drug applied on cancer cells and expression of genes were evaluated by Real- Time PCR and western blotting.
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Sajad Khiali , Afra Rezagholizadeh , Taher Entezari-Maleki*
In the present perspective piece, three possible mechanisms of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as an oncogenic virus in the lung have been discussed.
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Javad Firouzi , Fattah Sotoodehnejadnematalahi, Alireza Shokouhifar , Mahsa Rahimi, Niloufar Sodeifi, Parisa Sahranavardfar, Masoumeh Azimi, Ehsan Janzamin, Majid Safa, Marzieh Ebrahimi*
The effect of silibinin evaluated on self-renewal, tumorgenicity, and metastasis potential of Mammospheres derived from MCF-7, MDA-MB231 cell lines, and MDA-MB468 aggregated cells
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Laura Cabeza , Mazen M. El-Hammadi , Raul Ortiz , Maria D. Cayero-Otero, Julia Jiménez-López , Gloria Perazzoli , Lucia Martin-Banderas , Jose M. Baeyens , Consolación Melguizo* , Jose Prados
These results suggest that our PTX-PLGA NPs could be a suitable strategy for breast cancer therapy, improving antitumor drug efficiency and reducing systemic toxicity without altering its mechanism of action.
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Nasrollah Jabbari , Maryam Feghhi, Omid Esnaashari, Hamid Soraya, Jafar Rezaie*
Treatment of MCF-10a, MCF-7, and MDA-MD-231 cells with Gallic acid resulted in inhibition in the activity of the exosomal secretory pathway. Gallic acid can decrease the expression of genes involved in exosomes biogenesis (Alix and CD63) and secretion (Rab proteins). In addition, Gallic acid can change the expression of autophagy markers (LC3 and P62) in these cells. MVB: multivesicular body.
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Raghdah S. Bawadud , Mayson H. Alkhatib*
Co-delivery of NE-DTX+TQ may probably inhibit the proliferation of T47D via the induction of apoptosis and autophagy pathways and impede the migration by reducing the BCSC population and downregulating TWIST-1 expression to decrease the epithelial-to-mesenchymal transition (EMT) of breast cancer cells
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Atena Sharifi-Rad , Zeinab Amiri-Tehranizadeh, Atiye Talebi, Niknaz Nosrati, Morvarid Medalian, Mahtab Pejhan, Nazanin Hamzkanloo, Mohammad Reza Saberi, Parisa Mokaberi, Jamshidkhan Chamani*
The MD simulation and spectroscopic studies of the interaction of ct-DNA and propyl acridone revealed that a transition from the extended nucleic double helix towards the denatured structure.
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Behnaz Babaye Abdollahi , Marjan Ghorbani, Hamed Hamishehkar, Reza Malekzadeh, Alireza Farajollahi*
This study shows the positive effect of synthesized Trastuzumab loaded PEG-Fe3O4@Au nanoparticleson increasing the death rate of Breast cancer cells during megavoltage radiation therapy.
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Leila Rostamizadeh , Ommoleila Molavi* , Mohsen Rashid, Fatemeh Ramazani, Behzad Baradaran, Afsaneh Lavasanaifar, Raymond Lai
In this paper, we will review the application of the four most widely studied TLR agonists including agonists of TLR3, 4, 7, and 9 in cancer immunotherapy.
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Samaneh Tokhanbigli , Helia Alavifard , Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Kaveh Baghaei*
Combining LY6E loaded DC therapy with pioglitazone improved the DC therapy effect for colorectal cancer treatment. LY6E pulsed DCs excites the CD8 positive immune responses against colorectal models. Pioglitazone inhibits IL-6 axis and formation of CRC cell lines proliferation through IL-6/STAT3 by influencing the immunosuppressive feature of the tumor microenvironment.
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Mina Yousefnezhad, Soodabeh Davaran* , Mirzaagha Babazadeh, Abolfazl Akbarzadeh, Hamidreza Pazoki-Toroudi
Drug repurposing is an effective strategy for identifying and using approved drugs for new therapeutic purposes. We investigated co-delivery of the antitumor drugs, doxorubicin (DOX), and ezetimibe (EZ) as a cholesterol uptake-blocking drug with PCEC on prostate cancer cell line (PC3).
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Yalda Rahbar Saadat , Jaleh Barar*
Jaleh Barar (PharmD, Ph.D.) is a Full Professor at the Faculty of Pharmacy, Tabriz University of Medical Sciences. Professor Barar is working on various aspects of pharmaceutical cell biology with particular emphasis on the development of novel drug delivery/targeting systems. Dr Barar is listed among top 1% of world scientists based on ESI ranking system.
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Mitra Torabi , Ayuob Aghanejad*, Pouria Savadi , Abolfazl Barzegari, Yadollah Omidi , Jaleh Barar*
Owing to their unique advantages, mesoporous silica nanoparticles (MSNPs) have attracted much attention for drug delivery and targeting. In the current study, MSNPs were fabricated, PEGylated, loaded with sunitinib, and conjugated with mucin-16 aptamer to target CA125 on ovarian cancer cells.
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Zeinab Ghazvinian , Shahrokh Abdolahi, Mohammad Ahmadvand, Amir Hossein Emami, Samad Muhammadnejad, Hamid Asadzadeh Aghdaei, Jafar Ai, Mohammad Reza Zali, Iman Seyhoun, Javad Verdi* , Kaveh Baghaei*
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Sandeep Saini , Aayushi Rathore , Sheetal Sharma , Avneet Saini*
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Yuri Yu. Shchegolev , Danila V. Sorokin, Alexander M. Scherbakov* , Olga E. Andreeva , Diana I. Salnikova , Ekaterina I. Mikhaevich , Margarita V. Gudkova , Mikhail A. Krasil’nikov
Prolonged cell treatment with mTOR inhibitor rapamycin leads to the development of resistance. Exosomes of resistant cells induce the resistance to rapamycin in the parent MCF-7cells. Exosome-induced resistance reproduces the changes revealed in the rapamycin-resistant cells, including the activation of ERK/AP-1.
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Katelyn R. Einloth , Scott Gayfield, Thomas McMaster, Alexander Didier, Lance Dworkin, Justin Fortune Creeden*
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Nazila Jalilzadeh , Neda Barzgar Barough, Mehrdad Karami, Amir Baghbanzadeh, Kobra Velaei*
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Havva Afshari , Shokoofe Noori* , Mitra Nourbakhsh, Azam Daraei, Mahsa Azami Movahed, Afshin Zarghi
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Zeinab Mazloumi , Ali Rafat, Khadijeh Dizaji Asl, Mohammad Karimipour, Dariush Shanehbandi, Mehdi Talebi, Majid Montazer, Ali Akbar Movassaghpour, Alireza Dehnad, Raheleh Farahzadi, Hojjatollah Nozad Charoudeh*
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Mostafa Akbarzadeh-Khiavi , Azam Safary , Yadollah Omidi*
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Zahra Alidoost , Farnoosh Attari* , Fatemeh Saadatpour, Ehsan Arefian
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Farzaneh Bilan , Mohammad Amini, Mohammad Amin Doustvandi, Maryam Tohidast, Amir Baghbanzadeh, Seyed Samad Hosseini , Ahad Mokhtarzadeh* , Behzad Baradaran*
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Snehal Aditya Arvindekar* , Sanket Rathod , Prafulla Balkrishna Choudhari , Pradnya Kiran Mane , Aditya Umesh Arvindekar* , Suraj Narayan Mali , Bapu Thorat
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Hamed Zare , Hamid Bakherad* , Arman Nasr Esfahani, Mohamad Norouzi, Hossein Aghamollaei, Seyed Latif Mousavi Gargari, Fatemeh Mahmoodi, Mahdi Aliomrani, Walead Ebrahimizadeh
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Sepideh Parvizpour* , Hanieh Beyrampour-Basmenj, Jafar Razmara* , Farhad Farhadi, Mohd Shahir Shamsir
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Maryam Samareh Salavatipour , Zahra Poursalehi, Negin Hosseini Rouzbahani, Sohaib Mohammadyar, Mohammad Vasei*
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Ya-Lin Han , Li Chen, Xu-Ning Wang, Mao-Lin Xu, Rui Qin, Fang-Ming Gong, Peng Sun, Hong-Yi Liu, Zhi-Peng Teng, Zhao-Xia Li*, Guang-Hai Dai*
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