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Bioimpacts. 2016;6(2): 105-110. doi: 10.15171/bi.2016.15
PMID: 27525228        PMCID: PMC4981248

Original Research

Overexpression of molecular chaperons GRP78 and GRP94 in CD44hi/CD24lo breast cancer stem cells

Babak Nami 1 * ORCID, Armin Ghasemi-Dizgah 2, Akbar Vaseghi 3

Cited by CrossRef: 29

1- Direito I, Monteiro L, Melo T, Figueira D, Lobo J, Enes V, Moura G, Henrique R, Santos M, Jerónimo C, Amado F, Fardilha M, Helguero L. Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestrogens and Reveal the RNA Ligase RTCB as Mediator of Acquired Tamoxifen Resistance. Cancers. 2021;13(13):3195 [Crossref]
2- Zhang Y, Li S, He H, Han Q, Wang B, Zhu Y. Influence of Tanshinone IIA on apoptosis of human esophageal carcinoma Eca‐109 cells and its molecular mechanism. Thoracic Cancer. 2017;8(4):296 [Crossref]
3- Moriya C, Taniguchi H, Nagatoishi S, Igarashi H, Tsumoto K, Imai K. PRDM14 directly interacts with heat shock proteins HSP90α and glucose‐regulated protein 78. Cancer Science. 2018;109(2):373 [Crossref]
4- Liu C, Liu Y, Chen L, Zhang M, Li W, Cheng H, Zhang B. Quantitative proteome and lysine succinylome analyses provide insights into metabolic regulation in breast cancer. Breast Cancer. 2019;26(1):93 [Crossref]
5- Shah S, Rodriguez G, Musick A, Walters W, de Cordoba N, Barbarite E, Marlow M, Marples B, Prince J, Komotar R, Vanni S, Graham R. Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR). Cancers. 2019;11(2):159 [Crossref]
6- Bigdeli B, Goliaei B, Masoudi-Khoram N, Jooyan N, Nikoofar A, Rouhani M, Haghparast A, Mamashli F. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicology and Applied Pharmacology. 2016;313:180 [Crossref]
7- BAYKAL A, TURNA Ö. Current invasive and non-invasive biomarkers in canine mammary tumors. 2021;5(1):39 [Crossref]
8- Sunil Kumar B, Bhardwaj R, Mahajan K, Kashyap N, Kumar A, Verma R. The overexpression of Hsp90B1 is associated with tumorigenesis of canine mammary glands. Mol Cell Biochem. 2018;440(1-2):23 [Crossref]
9- Roudi R, Ebrahimi M, Shariftabrizi A, Madjd Z. Cancer stem cell research in Iran: potentials and challenges. Future Oncology. 2017;13(20):1809 [Crossref]
10- Nami B, Wang Z. Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance. Cancers. 2018;10(8):274 [Crossref]
11- Kahroba H, Shirmohamadi M, Hejazi M, Samadi N. The Role of Nrf2 signaling in cancer stem cells: From stemness and self-renewal to tumorigenesis and chemoresistance. Life Sciences. 2019;239:116986 [Crossref]
12- Conner C, Lager T, Guldner I, Wu M, Hishida Y, Hishida T, Ruiz S, Yamasaki A, Gilson R, Belmonte J, Gray P, Kelber J, Zhang S, Panopoulos A. Cell surface GRP78 promotes stemness in normal and neoplastic cells. Sci Rep. 2020;10(1) [Crossref]
13- McGrath E, Logue S, Mnich K, Deegan S, Jäger R, Gorman A, Samali A. The Unfolded Protein Response in Breast Cancer. Cancers. 2018;10(10):344 [Crossref]
14- Buc Calderon P, Beck R, Glorieux C. Targeting hsp90 family members: A strategy to improve cancer cell death. Biochemical Pharmacology. 2019;164:177 [Crossref]
15- Yadav K, Yadav A, Vashistha P, Pandey V, Dwivedi U. Protein Misfolding Diseases and Therapeutic Approaches. CPPS. 2019;20(12):1226 [Crossref]
16- Sadeghipour M, Torabizadeh S, Karimabad M. The Glucose-Regulated Protein78 (GRP78) in the Unfolded Protein Response (UPR) Pathway: A Potential Therapeutic Target for Breast Cancer. ACAMC. 2023;23(5):505 [Crossref]
17- Sun S, Kiang K, Ho A, Lee D, Poon M, Xu F, Pu J, Kan A, Lee N, Liu X, Man K, Day P, Lui W, Fung C, Leung G. Endoplasmic reticulum chaperone prolyl 4-hydroxylase, beta polypeptide (P4HB) promotes malignant phenotypes in glioma via MAPK signaling. Oncotarget. 2017;8(42):71911 [Crossref]
18- Marote A, Barroca N, Vitorino R, M. Silva R, H.V. Fernandes M, M. Vilarinho P, A.B. da Cruz e Silva O, I. Vieira S. A proteomic analysis of the interactions between poly(L-lactic acid) nanofibers and SH-SY5Y neuronal-like cells. 2016;3(4):661 [Crossref]
19- Hong S, Song J. 3D bioprinted drug-resistant breast cancer spheroids for quantitative in situ evaluation of drug resistance. Acta Biomaterialia. 2022;138:228 [Crossref]
20- Nami B, Wang Z. HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance. Cancers. 2017;9(5):40 [Crossref]
21- Li J, Han L, Zhan S, Li R, Wang Y, Qiu T, Zhang X. 1-MT grafted carboxymethyl chitosan and its nanoparticles: Preparation, characterization and evaluation. European Journal of Pharmaceutical Sciences. 2021;162:105829 [Crossref]
22- Shan N, Shin Y, Yang G, Furmanski P, Suh N. Breast cancer stem cells: A review of their characteristics and the agents that affect them. Molecular Carcinogenesis. 2021;60(2):73 [Crossref]
23- Amoroso F, Glass K, Singh R, Liberal F, Steele R, Maguire S, Tarapore R, Allen J, Van Schaeybroeck S, Butterworth K, Prise K, O’Sullivan J, Jain S, Waugh D, Mills I. Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells. Sci Rep. 2021;11(1) [Crossref]
24- Alhasan B, Mikeladze M, Guzhova I, Margulis B. Autophagy, molecular chaperones, and unfolded protein response as promoters of tumor recurrence. Cancer Metastasis Rev. 2023;42(1):217 [Crossref]
25- Zheng Z, Zuo Z, Zhu P, Wang F, Yin H, Peng X, Fang J, Cui H, Gao C, Song H, Ouyang P, Zhou Y, Zhao S. A study on the expression of apoptotic molecules related to death receptor and endoplasmic reticulum pathways in the jejunum of AFB1-intoxicated chickens. Oncotarget. 2017;8(52):89655 [Crossref]
26- Saleem A, Megha G, Zehra A. Novel promising serum biomarkers for canine mammary tumors. ProcIndian Natl Sci Acad. 2021;87(2):302 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge