Silibinin exhibits anti-tumor effects in a breast cancer stem cell model by targeting stemness and induction of differentiation and apoptosis

Javad Firouzi ^1,2,3 , Fattah Sotoodehnejadnematalahi ⁴, Alireza Shokouhifar ³ , Mahsa Rahimi ³, Niloufar Sodeifi ⁵, Parisa Sahranavardfar ³, Masoumeh Azimi ³, Ehsan Janzamin ³, Majid Safa ^1,2,6, Marzieh Ebrahimi ³ *

Cited by CrossRef: 6

1- Wang Y, Yuan A, Wu Y, Wu L, Zhang L. Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations. Journal of Functional Foods. 2023;100:105384 [Crossref]

2- Cui D, Zhang C, Zhang L, Zheng J, Wang J, He L, Jin H, Kang Q, Zhang Y, Li N, Sun Z, Zheng W, Wei J, Zhang S, Feng Y, Tan W, Zhong Z. Natural anti-cancer products: insights from herbal medicine. Chin Med. 2025;20(1) [Crossref]

3- Mohammadi D, Aghayan A, Mohammadi D, Mashhadi M, Jamalpoor Z, Rahdar A, Pandey S. Therapeutic Effects of Silibinin on Animal Models of Skin Cancer: A Systematic Review and Meta-Analysis. BioNanoSci. 2025;15(3) [Crossref]

4- Li H, Li J, Zhang Y, Zhao C, Ge J, Sun Y, Fu H, Li Y. The therapeutic effect of traditional Chinese medicine on breast cancer through modulation of the Wnt/β-catenin signaling pathway. Front Pharmacol. 2024;15 [Crossref]

5- Zavareh V, Gharibi S, Hosseini Rizi M, Nekookar A, Mirhendi H, Rahimmalek M, Szumny A. Satureja bachtiarica Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells. Cells. 2023;12(23):2713 [Crossref]

6- Golubnitschaja O, Kapinova A, Sargheini N, Bojkova B, Kapalla M, Heinrich L, Gkika E, Kubatka P. Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation. EPMA Journal. 2024;15(2):163 [Crossref]

7- Rizwan M, Naseem S, Durrani A. Pharmacokinetics and Therapeutic Potential of Milk Thistle Extracted Phytoconstituents: A Leading Role in Cancer Treatment. Trends Med Sci. 2023;3(2) [Crossref]

8- Koushki M, Farrokhi Yekta R, Amiri-Dashatan N. Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid. Journal of Functional Foods. 2023;104:105502 [Crossref]

9- Zhu K, Ni H, Hafeez E, Hu Y, Hu F, Du D, Chen D. Effects of Silibinin on Delaying Aging in Drosophila melanogaster. Antioxidants. 2025;14(2):147 [Crossref]

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