Silibinin exhibits anti-tumor effects in a breast cancer stem cell model by targeting stemness and induction of differentiation and apoptosis

Javad Firouzi ^1,2,3 , Fattah Sotoodehnejadnematalahi ⁴, Alireza Shokouhifar ³ , Mahsa Rahimi ³, Niloufar Sodeifi ⁵, Parisa Sahranavardfar ³, Masoumeh Azimi ³, Ehsan Janzamin ³, Majid Safa ^1,2,6, Marzieh Ebrahimi ³ *

Cited by CrossRef: 6

1- Wang Y, Yuan A, Wu Y, Wu L, Zhang L. Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations. Journal of Functional Foods. 2023;100:105384 [Crossref]

2- Li H, Li J, Zhang Y, Zhao C, Ge J, Sun Y, Fu H, Li Y. The therapeutic effect of traditional Chinese medicine on breast cancer through modulation of the Wnt/β-catenin signaling pathway. Front Pharmacol. 2024;15 [Crossref]

3- Zavareh V, Gharibi S, Hosseini Rizi M, Nekookar A, Mirhendi H, Rahimmalek M, Szumny A. Satureja bachtiarica Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells. Cells. 2023;12(23):2713 [Crossref]

4- Golubnitschaja O, Kapinova A, Sargheini N, Bojkova B, Kapalla M, Heinrich L, Gkika E, Kubatka P. Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation. EPMA Journal. 2024;15(2):163 [Crossref]

5- Rizwan M, Naseem S, Durrani A. Pharmacokinetics and Therapeutic Potential of Milk Thistle Extracted Phytoconstituents: A Leading Role in Cancer Treatment. Trends Med Sci. 2023;3(2) [Crossref]

6- Koushki M, Farrokhi Yekta R, Amiri-Dashatan N. Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid. Journal of Functional Foods. 2023;104:105502 [Crossref]

7- Zhu K, Ni H, Hafeez E, Hu Y, Hu F, Du D, Chen D. Effects of Silibinin on Delaying Aging in Drosophila melanogaster. Antioxidants. 2025;14(2):147 [Crossref]

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