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Bioimpacts. 2019;9(1): 1-3.
doi: 10.15171/bi.2019.01
PMID: 30788254
PMCID: PMC6378097
Scopus ID: 85060480524
WOSID: 000462994200001
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Editorial

Indoleamine 2, 3-dioxygenase inhibitors in immunochemotherapy of breast cancer: challenges and opportunities

Nastran Hashemzadeh 1,2, Khosro Adibkia 1,3 ORCID logo, Jaleh Barar 1,3 * ORCID logo

1 Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
2 Students' Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Trafficking of macromolecular immunotherapy agent into the tumor microenvironment (TME) is a challenging issue. In the TME, cancer cells exploit indoleamine 2, 3-dioxygenase (IDO), as a cytosolic enzyme that catalyzes the L-tryptophan (Trp) through the kynurenine (Kyn) pathway, which could negatively regulate the activity of T cells. Thus, Trp/Kyn pathway, can be targeted with novel treatment modalities such as IDO1 inhibitor to benefit patients with aggressive solid tumors. 
Keywords: Indoleamine 2, 3-dioxygenase, Kynurenine, Immunotherapy, IDO inhibitor, Solid tumors, Cancer therapy
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Submitted: 07 Oct 2018
Accepted: 08 Oct 2018
ePublished: 21 Oct 2018
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