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Editorial
Nastran Hashemzadeh, Khosro Adibkia ORCID, Jaleh Barar* ORCID
Bioimpacts. 2019;9(1): 1-3. doi: 10.15171/bi.2019.01
PMCID: PMC6378097     PMID: 30788254     Scopus ID: 85060480524     WOS: 000462994200001    

Original Research
Zahra Karimzadeh, Siamak Javanbakht, Hassan Namazi*
Bioimpacts. 2019;9(1): 5-13. doi: 10.15171/bi.2019.02
PMCID: PMC6378098     PMID: 30788255     Scopus ID: 85060437287     WOS: 000462994200002    
Carboxymethylcellulose/MOF-5/Graphene oxide bio-nanocomposite was synthesized through a solvothermal technique, which it could encapsulate tetracycline. The drug release tests showed the stability of drug dosing in the gastrointestinal tract conditions. Antibacterial tests exhibited suitable activity to negatively charge E. coli bacteria.

Original Research
Azam Safary ORCID, Rezvan Moniri, Maryam Hamzeh-Mivehroud, Siavoush Dastmalchi*
Bioimpacts. 2019;9(1): 15-23. doi: 10.15171/bi.2019.03
PMCID: PMC6378094     PMID: 30788256     Scopus ID: 85060439417     WOS: 000462994200003    
The current study introduces a new and efficient recombinant L-asparaginase (ASPase) enzyme from locally isolated halo-thermotolerant Bacillus. The activity assay of ASPase A1 and ASPase A3 showed that only ASPase A1 is an active and stable homologues enzyme with high substrate affinity toward L-asparagine.

Original Research
Cécilia Delattre*, Diego Velazquez, Caroline Roques, Graciela Pavon-Djavid, Véronique Ollivier, Anna Lokajczyk, Thierry Avramoglou, Virginie Gueguen, Liliane Louedec, Giuseppina Caligiuri, Martine Jandrot-Perrus, Catherine Boisson-Vidal, Didier Letourneur, Anne Meddahi-Pelle
Bioimpacts. 2019;9(1): 25-36. doi: 10.15171/bi.2019.04
PMCID: PMC6378099     PMID: 30788257     Scopus ID: 85060479725     WOS: 000462994200004    
Schematic illustration of the subsequent steps for the stents coating process and the evaluation of their biocompatibility: in vitro, ex vivo and in vivo (abdominal aorta stenting and stent restenosis preclinical models) evaluation of Dex-PBMA.

Original Research
Ramanjot Kaur, Ameya Sharma, Vivek Puri, Inderbir Singh*
Bioimpacts. 2019;9(1): 37-43. doi: 10.15171/bi.2019.05
PMCID: PMC6378101     PMID: 30788258     Scopus ID: 85060488714     WOS: 000462994200005    
Biocomposite films of biocomposite films of Carrageenan/Locust Bean Gum/Montmorillonite were prepared for the transdermal delivery of curcumin. Biocomposite films were effective in terms of physicochemical properties and were effective in wound care management.

Original Research
Sepideh Parvizpour, Jafar Razmara, Mohammad M. Pourseif, Yadollah Omidi* ORCID
Bioimpacts. 2019;9(1): 45-56. doi: 10.15171/bi.2019.06
PMCID: PMC6378095     PMID: 30788259     Scopus ID: 85060470196     WOS: 000462994200006    
Using immunoinformatic tools, a multi-epitope peptide vaccine (consisting of CD8+cytotoxic T lymphocytes epitopes, helper epitopes and adjuvant) was designed to combat the triple-negative breast cancer. The vaccine showed acceptable immunogenicity and potential to stimulate both cellular and humoral immune responses.

Original Research
Tatiana Matvienko, Viktoriya Sokolova, Svitlana Prylutska, Yuliia Harahuts, Nataliya Kutsevol, Viktor Kostjukov, Maxim Evstigneev* ORCID, Yuriy Prylutskyy*, Matthias Epple, Uwe Ritter
Bioimpacts. 2019;9(1): 57-63. doi: 10.15171/bi.2019.07
PMCID: PMC6378100     PMID: 30788260     Scopus ID: 85060451771     WOS: 000462994200007    
It was found that the Dextran-PNIPAM+Dox nanofluid in contrast to Dox alone showed higher toxicity towards HeLa cells, whereas the SWCNT+Dox and GO+Dox nanofluids protected cells from Dox.