Bioimpacts. 2019;9(1):37-43.
doi: 10.15171/bi.2019.05
PMID: 30788258
PMCID: PMC6378101
Scopus id: 85060488714
  Abstract View: 205
  PDF Download: 124
  Full Text View: 39

Original Research

Preparation and characterization of biocomposite films of carrageenan/locust bean gum/montmorrillonite for transdermal delivery of curcumin 

Ramanjot Kaur 1, Ameya Sharma 1, Vivek Puri 1, Inderbir Singh 1 *

1 Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Rajpura-140401, Patiala, Punjab, India
*Corresponding author: Inderbir Singh, Email: Email: inderbir.singh@chitkara.edu.in

Abstract

Introduction: Skin can be used as a site for local and systemic drug administration. Diffusion of drugs through the skin has led to the development of different transdermal drug delivery systems. Curcumin is a wound healing and anti-inflammatory agent. Curcumin was incorporated into biocomposite films of carrageenan (κC)/locust bean gum (LBG)/ montmorillonite (MMT) prepared by a solvent casting method.

Methods: Film-forming solutions were prepared by adding and 2.5% v/v of propylene glycol and MMT (30% w/w). The curcumin loaded polymer composite transdermal films were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) spectroscopy and X-ray diffraction (XRD) analysis. Mechanical properties in terms of tensile strength and extensibility were studied. Films were also evaluated for moisture content, moisture uptake, thickness, folding endurance, swelling ratio and water vapor transmission rate (WVTR).

Results: κC and κC/L40 showed the highest percent cumulative release of 80.42±1.61% and 69.38±1.26% among all of the polymer composite transdermal films in 8 hours and 24 hours respectively.

Conclusion: In vitro release profiles showed that increasing concentration of LBG and MMT sustained the release of the drug from the polymer composite transdermal films. Decreased percent cumulative release as the concentration of LBG and MMT increases in polymer composite transdermal film.

First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 205

Your browser does not support the canvas element.


PDF Downloaded: 124

Your browser does not support the canvas element.


Full Text Viewed: 39

Your browser does not support the canvas element.

Submitted: 09 May 2018
Revised: 25 May 2018
Accepted: 22 Sep 2018
First published online: 07 Oct 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)