Abstract
Introduction: In recent years, more attention was
dedicated to developing new methods for designing
of drug delivery systems. The aim of present work
is to improve the efficiency of the antibacterial
drug delivery process, and to realize and to control
accurately the release.
Methods: First, graphene oxide (GO) was prepared
according to the modified Hummers method then
the GO was modified with carboxymethylcellulose
(CMC) and Zn-based metal-organic framework (MOF-5) through the solvothermal technique.
Results: Performing the various analysis methods including scanning electron microscope (SEM),
X-ray diffraction (XRD), EDX, Fourier transform infrared (FTIR) spectroscopy and Zeta potentials
on the obtained bio-nanocomposite showed that the new modified GO has been prepared. With
using common analysis methods the structure of synthesized materials was determined and
confirmed and finally, their antibacterial behavior was examined based on the broth microdilution
methods.
Conclusion: Carboxymethylcellulose/MOF-5/GO bio-nanocomposite (CMC/MOF-5/GO) was
successfully synthesized through the solvothermal technique. Tetracycline (TC) was encapsulated
in the GO and CMC/MOF-5/GO. The drug release tests showed that the TC-loaded CMC/MOF5/GO has an effective protection against stomach pH. With controlling the TC release in the
gastrointestinal tract conditions, the long-time stability of drug dosing was enhanced. Furthermore,
antibacterial activity tests showed that the TC-loaded CMC/MOF-5/GO has an antibacterial
activity to negatively charge E. coli bacteria in contrast to TC-loaded GO.