Nanoencapsulation of Hirudo medicinalis proteins in liposomes as a nanocarrier for inhibiting angiogenesis through targeting VEGFA in the Breast cancer cell line (MCF-7)

Amir Shakouri ^1,2 , Houman Kahroba ², Hamed Hamishekar ¹, Jalal Abdolalizadeh ^3,4 *

Cited by CrossRef: 14

1- Ayhan H, Sevin S, Karaaslan S, Ayaz F. Immunomodulatory effects of medicinal leech saliva extract on in vitro activated macrophages. Immunol Res. 2025;73(1) [Crossref]

2- Li X, Zhou J, Wang X, Li C, Ma Z, Wan Q, Peng F. New advances in the research of clinical treatment and novel anticancer agents in tumor angiogenesis. Biomedicine & Pharmacotherapy. 2023;163:114806 [Crossref]

3- Özdemir S, Ayhan H. Anticancer Potential of Lyophilised Medicinal Leech (Hirudo verbana) of Saliva Extract Against Pancreatic Cancer (MIA PaCa-2) Cell Lines. 2025;10(2):167 [Crossref]

4- C Senan L, M S D. LEECH THERAPY- ITS ENTHRALLING ANNALS IN MEDICAL HISTORY. IAMJ. 2025;13(08):2345 [Crossref]

5- Dong B, Li C, Xu X, Wang Y, Li Y, Li X. LncRNA LINC01123 promotes malignancy of ovarian cancer by targeting hsa-miR-516b-5p/VEGFA. Genes Genom. 2024;46(2):231 [Crossref]

6- Valinezhadi N, Dehghan G, Yaghoubzad-Maleki M, Mohammadi M, Alizadeh A, Hamishehkar H. Liposome-assisted combination chemotherapy improves the anti-proliferation and anti-angiogenesis response of cisplatin in breast cancer; experimental and computational study. Journal of Chemotherapy. 2025;:1 [Crossref]

7- Sabaghi Y, PourFarzad F, Zolghadr L, Bahrami A, Shojazadeh T, Farasat A, Gheibi N. A nano-liposomal carrier containing p-coumaric acid for induction of targeted apoptosis on melanoma cells and kinetic modeling. Biochemical and Biophysical Research Communications. 2024;690:149219 [Crossref]

8- Dong J, Chen J, Li Q, Qiu S. Magnetic Double Hydrogen Artesunate Nano Liposome on CAL Tongue Squamous Carcinoma and Laryngeal Hep-2-27 Cell Lines: An In Vitro Study. j biomed nanotechnol. 2024;20(1):157 [Crossref]

9- Tural Ö, Ayhan H. The Anti-Proliferative Activity of Lyophilised Medicinal Leech (Hirudo Verbana) Saliva Extract on Breast Cancer Cell Line (MCF-7). 2024;9(4):508 [Crossref]

10- Bilden A, Sabancılar İ, Yalçın Azarkan S, Karadağlı K, Kaya S, Kahraman M, Çiçek M. Investigating the Therapeutic Potential of Crude Leech Saliva Based on Its Anticancer, Antioxidant, and Anti-Inflammatory Effects. CIMB. 2025;47(5):328 [Crossref]

11- Zheng X, Ke F, Yao M, Yang H, Luo Y, Liu X, Chen C, Zhang J, Guo X, Song C, Liu X, Wang D, Liu Q. Biophysical Properties of the Extracellular Matrix in Cancer: Insights Into Immunotherapy. Front Biosci (Landmark Ed). 2025;30(10) [Crossref]

12- Das S, Pattnaik G, Pattanaik S, Jena B, Satapathy B, Pradhan A. Envisioning Clinical Management of Breast Cancer: a Comprehensive Review. CDDT. 2025;22(2) [Crossref]

13- Bao Z, Qi X, Zhu S, Zhang M, Liu X, Chen P, Zhang L, Geng T, Cheng F. Recent progress on formulations of hirudin. Pharmaceutical Science Advances. 2025;3:100078 [Crossref]

Submit Your Paper Instructions for Authors Aims and Scope Editorial Board Editorial Policies Publication Ethics Policies Editorial Board Policy Abstracting and Indexing Archive

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences.
Acceptance rate (2024): 20%
Publication fee: Free of charge

Indexing/Abstracting Info
PubMed; PubMed Central; Scopus; Science Citation Index Expanded; Google Scholar; SJR; Essential Science Indicators; Embase; EBSCOhost; CAS: DOAJ: SHERPA/RoMEO
Member of
Follower of ICMJE
Permission: Creative Commons