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BioImpacts. 2021;11(4): 253-261. doi: 10.34172/bi.2021.36
PMID: 34631487        PMCID: PMC8494259

Original Research

Melatonin increases 5-flurouracil-mediated apoptosis of colorectal cancer cells through enhancing oxidative stress and downregulating survivin and XIAP

Ainaz Mihanfar 1, Bahman Yousefi 2, Saber Ghazizadeh Darband 3, Shirin Sadighparvar 4, Mojtaba Kaviani 5, Maryam Majidinia 6 * ORCID

Cited by CrossRef: 16

1- de Morais J, Cruz E, Concato V, de Souza M, Santos Y, Quadreli D, Inoue F, Ferreira F, Fernandes G, Bidóia D, Machado R, Chuffa L, Pavanelli W, Seiva F. Unraveling the impact of melatonin treatment: Oxidative stress, metabolic responses, and morphological changes in HuH7.5 hepatocellular carcinoma cells. Pathology - Research and Practice. 2024;253:155056 [Crossref]
2- Mafi A, Rezaee M, Hedayati N, Hogan S, Reiter R, Aarabi M, Asemi Z. Melatonin and 5-fluorouracil combination chemotherapy: opportunities and efficacy in cancer therapy. Cell Commun Signal. 2023;21(1) [Crossref]
3- Linowiecka K, Slominski A, Reiter R, Böhm M, Steinbrink K, Paus R, Kleszczyński K. Melatonin: A Potential Regulator of DNA Methylation. Antioxidants. 2023;12(6):1155 [Crossref]
4- Gao J, Hou Y, Yang X, Liu J, Zhang Y. Melatonin enhances the sensitivity of colorectal cancer cells to 5‐fluorouracil through the regulation of the miR‐532‐3p/β‐catenin pathway. Environmental Toxicology. 2024;39(1):367 [Crossref]
5- Gong Y, Hou F, Xiang C, Li C, Hu G, Chen C. The mechanisms and roles of melatonin in gastrointestinal cancer. Front Oncol. 2022;12 [Crossref]
6- Zeinali N, Mahmoudzadeh V, Anarjani A, Ebrahimnejad M, Yousefi B, Valizadeh A, Ergün S. Thymoquinone Increases the Sensitivity of SW‐480 Colon Cancer Cells to 5‐Fluorouracil. BioMed Research International. 2024;2024(1) [Crossref]
7- Pourhanifeh M, Hosseinzadeh A, Koosha F, Reiter R, Mehrzadi S. Therapeutic Effects of Melatonin in the Regulation of Ferroptosis: A Review of Current Evidence. CDT. 2024;25(8):543 [Crossref]
8- Florido J, Rodriguez-Santana C, Martinez-Ruiz L, López-Rodríguez A, Acuña-Castroviejo D, Rusanova I, Escames G. Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells. Antioxidants. 2022;11(8):1621 [Crossref]
9- Sajid A, Manzoor Q, Sajid A, Sajid M, Imtiaz F, Mumtaz M, Fatima N, Mohammed O, Abdel-Reheim M, Iqbal M. In vitro and In silico studies of terpenes extracted from Cymbopogon flexuous leaves against human myeloid leukemia as an inhibitor of NF-κB activation signaling pathway. Journal of Molecular Structure. 2025;1321:139675 [Crossref]
10- Luo S, Xu J, Mo C, Gong W, Li C, Hou X, Ou M. High-throughput sequencing reveals twelve cell death pattern prognostic target genes as potential drug-response-associated genes in the treatment of colorectal cancer cells with palmatine hydrochloride. 2024; [Crossref]
11- Elbanan M, Amer M, El-Missiry M, Othman A, Shabana S. Melatonin protects mice from 5-FU hepatotoxicity and improves 5-FU antitumor effects by an apoptotic pathway dependent on cell cycle arrest in A549 human lung cancer cells. 2023; [Crossref]
12- Park S, Ham J, Yang C, Park W, Park H, An G, Song J, Hong T, Park S, Kim H, Song G, Lim W. Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs. Journal of Pineal Research. 2023;74(1) [Crossref]
13- Ghareghomi S, Khatibi A, Majidinia M, Saso L, Salimi S. Exploring MIL-68(Al) nanocarrier for melatonin delivery: probing pro-oxidant effects in cancer cells and achieving sustained drug release. Journal of Industrial and Engineering Chemistry. 2025;142:206 [Crossref]
14- Farrash W, Aslam A, Almaimani R, Minshawi F, Almasmoum H, Alsaegh A, Iqbal M, Tabassum A, Elzubier M, El‐Readi M, Mahbub A, Idris S, Refaat B. Metformin and thymoquinone co‐treatment enhance 5‐fluorouracil cytotoxicity by suppressing the PI3K/mTOR/HIF1α pathway and increasing oxidative stress in colon cancer cells. BioFactors. 2023;49(4):831 [Crossref]
15- Reiter R, Sharma R, Tan D, Huang G, de Almeida Chuffa L, Anderson G. Melatonin modulates tumor metabolism and mitigates metastasis. Expert Review of Endocrinology & Metabolism. 2023;18(4):321 [Crossref]
16- Bedoya-Betancur V, Correa E, Rendón J, Yepes-Pérez A, Cardona-Galeano W, Naranjo T. Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis. Molecules. 2022;27(20):7108 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
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