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BioImpacts. 2021;11(4): 253-261. doi: 10.34172/bi.2021.36
PMID: 34631487        PMCID: PMC8494259

Original Research

Melatonin increases 5-flurouracil-mediated apoptosis of colorectal cancer cells through enhancing oxidative stress and downregulating survivin and XIAP

Ainaz Mihanfar 1, Bahman Yousefi 2, Saber Ghazizadeh Darband 3, Shirin Sadighparvar 4, Mojtaba Kaviani 5, Maryam Majidinia 6 * ORCID

Cited by CrossRef: 8

1- Elbanan M, Amer M, El-Missiry M, Othman A, Shabana S. Melatonin protects mice from 5-FU hepatotoxicity and improves 5-FU antitumor effects by an apoptotic pathway dependent on cell cycle arrest in A549 human lung cancer cells. 2023;2(4) [Crossref]
2- de Morais J, Cruz E, Concato V, de Souza M, Santos Y, Quadreli D, Inoue F, Ferreira F, Fernandes G, Bidóia D, Machado R, Chuffa L, Pavanelli W, Seiva F. Unraveling the impact of melatonin treatment: Oxidative stress, metabolic responses, and morphological changes in HuH7.5 hepatocellular carcinoma cells. Pathology - Research and Practice. 2024;253:155056 [Crossref]
3- Mafi A, Rezaee M, Hedayati N, Hogan S, Reiter R, Aarabi M, Asemi Z. Melatonin and 5-fluorouracil combination chemotherapy: opportunities and efficacy in cancer therapy. Cell Commun Signal. 2023;21(1) [Crossref]
4- Linowiecka K, Slominski A, Reiter R, Böhm M, Steinbrink K, Paus R, Kleszczyński K. Melatonin: A Potential Regulator of DNA Methylation. Antioxidants. 2023;12(6):1155 [Crossref]
5- Gao J, Hou Y, Yang X, Liu J, Zhang Y. Melatonin enhances the sensitivity of colorectal cancer cells to 5‐fluorouracil through the regulation of the miR‐532‐3p/β‐catenin pathway. Environmental Toxicology. 2024;39(1):367 [Crossref]
6- Park S, Ham J, Yang C, Park W, Park H, An G, Song J, Hong T, Park S, Kim H, Song G, Lim W. Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs. Journal of Pineal Research. 2023;74(1) [Crossref]
7- Farrash W, Aslam A, Almaimani R, Minshawi F, Almasmoum H, Alsaegh A, Iqbal M, Tabassum A, Elzubier M, El‐Readi M, Mahbub A, Idris S, Refaat B. Metformin and thymoquinone co‐treatment enhance 5‐fluorouracil cytotoxicity by suppressing the PI3K/mTOR/HIF1α pathway and increasing oxidative stress in colon cancer cells. BioFactors. 2023;49(4):831 [Crossref]
8- Gong Y, Hou F, Xiang C, Li C, Hu G, Chen C. The mechanisms and roles of melatonin in gastrointestinal cancer. Front Oncol. 2022;12 [Crossref]
9- Reiter R, Sharma R, Tan D, Huang G, de Almeida Chuffa L, Anderson G. Melatonin modulates tumor metabolism and mitigates metastasis. Expert Review of Endocrinology & Metabolism. 2023;18(4):321 [Crossref]
10- Bedoya-Betancur V, Correa E, Rendón J, Yepes-Pérez A, Cardona-Galeano W, Naranjo T. Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis. Molecules. 2022;27(20):7108 [Crossref]
11- Florido J, Rodriguez-Santana C, Martinez-Ruiz L, López-Rodríguez A, Acuña-Castroviejo D, Rusanova I, Escames G. Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells. Antioxidants. 2022;11(8):1621 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
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