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Bioimpacts. 2019;9(3): 123-127. doi: 10.15171/bi.2019.16
PMID: 31508327        PMCID: PMC6726747

Editorial

Recent advances in targeted therapy of colorectal cancer: impacts of monoclonal antibodies nanoconjugates

Mostafa Akbarzadeh Khiavi 1,2 ORCID, Azam Safary 2,3 ORCID, Mohammad Hossein Somi 1 * ORCID

Cited by CrossRef: 24

1- Lotfi F, Akbarzadeh-Khiavi M, Lotfi Z, Rahbarnia L, Safary A, Zarredar H, Baghbanzadeh A, Naghili B, Baradaran B. Micronutrient therapy and effective immune response: a promising approach for management of COVID-19. Infection. 2021;49(6):1133 [Crossref]
2- Akbarzadeh Khiavi M, Safary A, Barar J, Farzi-Khajeh H, Barzegari A, Mousavi R, Somi M, Omidi Y. PEGylated gold nanoparticles-ribonuclease induced oxidative stress and apoptosis in colorectal cancer cells. Bioimpacts. 2019;10(1):27 [Crossref]
3- Akbarzadeh-Khiavi M, Safary A. Effect of nano-formulated Panitumumab on AKT/PTEN/caspase 3 apoptosis and gene expression and BAX/Bcl2 signaling pathway in KRAS-mutant SW480 cells. Med J Tabriz Uni Med Sciences. 2025;47(3):274 [Crossref]
4- Alizadeh S, Esmaeili A, Barar J, Omidi Y. Optogenetics: A new tool for cancer investigation and treatment. Bioimpacts. 2022;12(4):295 [Crossref]
5- Balakarthikeyan J, Mayakrishnan V, Kannappan P, Al-Ghamdi S, Alrudian N, Alqahtani M, El-Bidawy M, Albasheer K, Gamil S, Alsanousi N, Ramesh T. Cetuximab-conjugated andrographolide loaded chitosan-pectin composite nanoparticles for colorectal cancer. Journal of King Saud University - Science. 2024;36(7):103261 [Crossref]
6- Yang X, Luo Z, Fang D, Chen Q, Peng N, Fang H, Zou T. Hollow Copper Sulfide Nanocubes Loaded with Pt(IV) Complexes for Cancer Multimodal Therapy. Langmuir. 2024;40(43):22875 [Crossref]
7- Lucía C. Future directions in cancer immunotherapy with monoclonal antibodies. RRP. 2022;8(4):101 [Crossref]
8- Akbarzadeh-Khiavi M, Torabi M, Olfati A, Rahbarnia L, Safary A. Bio-nano scale modifications of melittin for improving therapeutic efficacy. Expert Opinion on Biological Therapy. 2022;22(7):895 [Crossref]
9- Akbarzadeh Khiavi M, Safary A, Barar J, Ajoolabady A, Somi M, Omidi Y. Multifunctional nanomedicines for targeting epidermal growth factor receptor in colorectal cancer. Cell Mol Life Sci. 2020;77(6):997 [Crossref]
10- Mihanfar A, Yousefi B, Ghazizadeh Darband S, Sadighparvar S, Kaviani M, Majidinia M. Melatonin increases 5-flurouracil-mediated apoptosis of colorectal cancer cells through enhancing oxidative stress and downregulating survivin and XIAP. Bioimpacts. 2020;11(4):253 [Crossref]
11- Rao J, Wan X, Tou F, He Q, Xiong A, Chen X, Cui W, Zheng Z. Molecular Characterization of Advanced Colorectal Cancer Using Serum Proteomics and Metabolomics. Front Mol Biosci. 2021;8 [Crossref]
12- Khelwatty S, Puvanenthiran S, Essapen S, Bagwan I, Seddon A, Modjtahedi H. HER2 Expression Is Predictive of Survival in Cetuximab Treated Patients with RAS Wild Type Metastatic Colorectal Cancer. Cancers. 2021;13(4):638 [Crossref]
13- Swastha D, Varsha N, Aravind S, Samyuktha K, Yokesh M, Balde A, Ayilya B, Benjakul S, Kim S, Nazeer R. Alginate-based drug carrier systems to target inflammatory bowel disease: A review. International Journal of Biological Macromolecules. 2023;244:125472 [Crossref]
14- Jin K, Chen B, Liu Y, Lan H, Yan J. Monoclonal antibodies and chimeric antigen receptor (CAR) T cells in the treatment of colorectal cancer. Cancer Cell Int. 2021;21(1) [Crossref]
15- Olfati A, Safary A, Akbarzadeh-Khiavi M, Adibkia K. Recent advances in protein corona and practical applications of nanoparticle-based therapeutic agents. Journal of Drug Delivery Science and Technology. 2023;87:104844 [Crossref]
16- Chen R, Huang Y, Wang L, Zhou J, Tan Y, Peng C, Yang P, Peng W, Li J, Gu Q, Sheng Y, Wang Y, Shao G, Zhang Q, Sun Y. Cetuximab functionalization strategy for combining active targeting and antimigration capacities of a hybrid composite nanoplatform applied to deliver 5-fluorouracil: toward colorectal cancer treatment. Biomater Sci. 2021;9(6):2279 [Crossref]
17- Wong K. Integrated transcriptomics and proteomics data analysis identifies CDH17 as a key cell surface target in colorectal cancer. Computational Biology and Chemistry. 2023;105:107897 [Crossref]
18- Jafary B, Akbarzadeh-Khiavi M, Farzi-Khajeh H, Safary A, Adibkia K. EGFR-targeting RNase A-cetuximab antibody-drug conjugate induces ROS-mediated apoptosis to overcome drug resistance in KRAS mutant cancer cells. Sci Rep. 2025;15(1) [Crossref]
19- Tong G, Luo Q, Pang X, Chen B, Lv G, Li X, Wang S. Retrospective Analyses of Complete Resection Combined with Systemic Chemotherapy and Targeted Therapy for Patients with Ovarian Metastases from Colorectal Cancer. Cancer Biotherapy and Radiopharmaceuticals. 2022;37(7):553 [Crossref]
20- Fathi M, Safary A, Barar J. Therapeutic impacts of enzyme-responsive smart nanobiosystems. Bioimpacts. 2019;10(1):1 [Crossref]
21- Ghani S, Bahrami S, Rafiee B, Eyvazi S, Yarian F, Ahangarzadeh S, Khalili S, Shahzamani K, Jafarisani M, Bandehpour M, Kazemi B. Recent developments in antibody derivatives against colorectal cancer; A review. Life Sciences. 2021;265:118791 [Crossref]
22- Roudi R, Barodabi M, Madjd Z, Roviello G, Corona S, Panahi M. Expression patterns and clinical significance of the potential cancer stem cell markers OCT4 and NANOG in colorectal cancer patients. Molecular & Cellular Oncology. 2020;7(5) [Crossref]
23- Akbarzadeh-Khiavi M, Farzi-Khajeh H, Somi M, Safary A, Barar J, Ansari R, Omidi Y. Eradication of KRAS mutant colorectal adenocarcinoma by PEGylated gold nanoparticles-cetuximab conjugates through ROS-dependent apoptosis. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2022;653:129890 [Crossref]

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As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate (2024): 20% 
Publication fee: Free of charge

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