Bioimpacts. 2018;8(3): 223-235.
doi: 10.15171/bi.2018.25
PMID: 30211082
PMCID: PMC6128970
Scopus ID: 85050689925
WOSID: 000442045800009
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Breast cancer vaccination comes to age: impacts of bioinformatics

Sepideh Parvizpour 1, Jafar Razmara 2, Yadollah Omidi 1,3 * ORCID logo

1 Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Computer Science, Faculty of mathematical Sciences, University of Tabriz, Tabriz, Iran
3 Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran


Introduction: Breast cancer, as one of the major causes of cancer death among women, is the central focus of this study. The recent advances in the development and application of computational tools and bioinformatics in the field of immunotherapy of malignancies such as breast cancer have emerged the new dominion of immunoinformatics, and therefore, next generation of immunomedicines.
Methods: Having reviewed the most recent works on the applications of computational tools, we provide comprehensive insights into the breast cancer incidence and its leading causes as well as immunotherapy approaches and the future trends. Furthermore, we discuss the impacts of bioinformatics on different stages of vaccine design for the breast cancer, which can be used to produce much more efficient vaccines through a rationalized time- and cost-effective in silico approaches prior to conducting costly experiments.
Results: The tools can be significantly used for designing the immune system-modulating drugs and vaccines based on in silico approaches prior to in vitro and in vivo experimental evaluations. Application of immunoinformatics in the cancer immunotherapy has shown its success in the pre-clinical models. This success returns back to the impacts of several powerful computational approaches developed during the last decade.
Conclusion: Despite the invention of a number of vaccines for the cancer immunotherapy, more computational and clinical trials are required to design much more efficient vaccines against various malignancies, including breast cancer.

Keywords: Bioinformatics, Cancer, Epitope-based vaccine design, Vaccine design
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Submitted: 11 Mar 2018
Revision: 02 Apr 2018
Accepted: 03 Apr 2018
ePublished: 18 Apr 2018
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