Bioimpacts. 2020;10(1): 55-61.
doi: 10.15171/bi.2020.07
PMID: 31988857
PMCID: PMC6977589
Scopus ID: 85078968516
  Abstract View: 250
  PDF Download: 196
  Full Text View: 131

Original Research

Role of the Kölliker-Fuse nucleus in cardiovascular responses to hypoxia and baroreceptor activation in anesthetized rats

Nafiseh Mirzaei-Damabi 1 ORCID logo, Bahar Rostami 1, Masoumeh Hatam 1 * ORCID logo

1 Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


Introduction: Parabrachial Kölliker-Fuse (KF) complex, located in dorsolateral part of the pons, is involved in the respiratory control, however, its role in the baroreflex and chemoreflex responses has not been established yet. This study was performed to test the contribution of the KF to chemoreflex and baroreflex and the effect of microinjection of a reversible synaptic blocker (Cocl2) into the KF in urethane anesthetized rats.
Methods: Activation of chemoreflex was induced by systemic hypoxia caused by N2 breathing for 30 seconds "hypoxic- hypoxia methods” and baroreflex was evoked by intravenous injection (i.v.) of phenylephrine (Phe, 20 µg /kg/0.05–0.1 mL). N2 induced generalized vasodilatation followed by tachycardia reflex and Phe evoked vasoconstriction followed by bradycardia.
Results: Microinjection of Cocl2 (5 mM/100 nL/side) produced no significant changes in the Phe-induced hypertension and bradycardia, whereas the cardiovascular effect of N2 was significantly attenuated by the injection of CoCl2 to the KF.
Conclusion: The KF played no significant role in the baroreflex, but could account for cardiovascular chemoreflex in urethane anesthetized rats.
Keywords: Chemoreflex, Baroreflex, Kölliker-Fuse, Cobalt chloride
First Name
Last Name
Email Address
Security code

Abstract View: 250

Your browser does not support the canvas element.

PDF Download: 196

Your browser does not support the canvas element.

Full Text View: 131

Your browser does not support the canvas element.

Submitted: 01 Sep 2019
Revision: 09 Oct 2019
Accepted: 13 Oct 2019
ePublished: 02 Nov 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)