Bioimpacts. 2020;10(1): 1-4.
doi: 10.15171/bi.2020.01
PMID: 31988850
PMCID: PMC6977590
Scopus ID: 85078980716
  Abstract View: 348
  PDF Download: 330
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Therapeutic impacts of enzyme-responsive smart nanobiosystems

Marziyeh Fathi 1 ORCID logo, Azam Safary 1,2 ORCID logo, Jaleh Barar 1,3 * ORCID logo

1 Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
2 Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran


An important arena of the sophisticated nanosystems (NSs) is the combination of the responsive features of NSs with the biocatalytic properties of enzymes. The development of such smart drug delivery systems (DDSs) has seminal effectiveness in targeting, imaging, and monitoring of cancer. These NSs can exhibit site-specific delivery of the toxic cargo in response to the endogenous/exogenous stimuli. Enzyme responsive/targeted DDSs display enhanced accumulation of cargo molecules in the tumor microenvironment (TME) with a spatiotemporal controlled-release behavior. Based on the unique features of enzyme responsive/targeted DDSs, they offer incredible promise in overcoming some limitations of the currently used conventional DDSs. Taken all, targeting TME with the enzyme-responsive targeted DDSs may lead to versatile clinical outcomes in various malignancies.
Keywords: Enzyme-responsive, Smart drug delivery system, Tumor targeting, Nanomaterial, Stimuli-responsive
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Submitted: 11 Sep 2019
Revision: 21 Oct 2019
Accepted: 11 Nov 2019
ePublished: 25 Nov 2019
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