Bioimpacts. 2019;9(3):179-189.
doi: 10.15171/bi.2019.22
  Abstract View: 83
  PDF Download: 1

Original Research

Electrosprayed Polymeric Nanobeads and Nanofibers of Modafinil: Preparation, Characterization, and Drug Release Studies

Abstract

Introduction: Modafinil (MDF) is used orally for the treatment of attention-deficit/hyperactivity disorder and narcolepsy. It has low solubility and high permeability, therefore improving its dissolution properties by preparing nanoformulations can be a promising approach to enhance its oral absorption. Our aims are to prepare and characterize modafinil-Eudragit® RS100 (MDF-ERS) nanoparticles by electrospray technique. Methods: Electrosprayed nanoparticles were fabricated by varying MDF to ERS ratios and concentrations. The formulations were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FTIR). Release studies were performed on nanoparticles, physical mixtures, and raw modafinil. The release data were fitted to different models to understand the mechanism of the drug release. Results: Electrospraying of MDF and ERS solution resulted in the preparation of nonobeads or nanofibers and particulate characteristics of the obtained products were largely controlled by polymer amount in the solution. PXRD and thermal analyses showed that MDF was an amorphous phase the structures of nanoparticles. Using FTIR, no interaction was observed between MDF and ERS in nanoparticles. Nanoparticles showed biphasic release profiles and the order of dissolution rates was as: nanofibers>MDF>nanobeads. The well-fitted model was Weibull model, indicating a Fickian diffusion as the main mechanism of release. Conclusion: The results suggest that by optimization of variable such as solution concentration MDF-ERS nanofibers and nanobeads with higher dissolution rates can be prepared by electrospray. Electrospray deposition as a simple, continuous, and surfactant free method is an excellent choice for preparation of drug loaded polymeric nanoparticles.
First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 83

Your browser does not support the canvas element.


PDF Downloaded: 1

Your browser does not support the canvas element.

Submitted: 23 Jul 2018
Revised: 20 Nov 2018
Accepted: 27 Nov 2018
First published online: 15 Apr 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)