Colorectal cancer (CRC) as a malignancy shows high mortality rate worldwide because of metastasis and drug resistance. Targeted multimodal nanosystems (NSs) can be developed and used against CRC with much better clinical outcomes.

Editorial
Bioimpacts. 2019;9(3):129-130. doi: 10.15171/bi.2019.17
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Scientific bullying, as a growing concern, may emerge differently (from insults/snubs to violations of intellectual properties). Strategies such as specific training and detailed examination might be helpful for those at risk of bullying.

The minigene vaccine construct is designed based on the B and T cell epitopes of E. granulosus enolase protein, and ligands for TLR-2 and TLR-4. The minigene vaccine showed stable properties for proper binding with the Toll-like receptors.

Increased expression of TSGA10 associated with the reduced metastasis in the MDA-MB-231 cells. TSGA10 showed interaction with HIF-1α with high affinity. TSGA10 expression is altered under the hypoxia, indicating its potential as a bio-target for cancer therapy.

The purification process for stromal vascular fraction (SVF) can be performed using additional short plastic adherence incubation step (16-20h). This process leads in 24h to a predictable GMP-compliant cell-product. This product is more homogenous than the SVF.

Supplementation with Nigella Sativa and nano-sized clinoptilolite in rats with diabetes mellitusinduced with high-fat diet and injection of 35 mg/kg BW of streptozotocin, resulted in asignificant increase in calcium, alkaline phosphatase, and parathyroid hormone levels.

Electrospraying of modafinil and Eudragit RS100 using different drug: polymer ratios and various solution concentrations can lead to the formation of unique nanostructures such as nonobeads and nanofibers depending on the polymer concentration in the feed solution.

Two lateralities in the same side considerably might imply the solidarity in the control of the dominant brain hemisphere, while the unilaterality appears to be more prominent. Thus, masticatory preference is found with probable origins in the dominant hemisphere of the brain.