Alireza Farnam
1, Ali Fakhari
1, Leila Roshangar
2, Sajjad Kahni
3, Sara Farhang
1*1 Research Team for Psychiatry and Behavioral Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Anatomy and Histology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 Research Centre for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Introduction: Interaction
of several genes is responsible for psychiatric diseases such as
depression. Despite the numerous microarray studies in this field,
findings are controversial and hard to conclude. Methods:
Male Wistar rats were randomly selected to receive Chronic Mild Stress
model for 4 weeks. Different aspects of depression were measured by
forced swimming test, open field trial and sucrose preference tests in
the experience group and controls. Results:
Sucrose was preferred by 40% of CMS group and 80% of controls (p=0.025).
Twenty percent of CMS group and 80% of controls were “active”
(p=0.001). Last escape was at minute 238 for CMS group and minute 245
for controls and controls had more escape efforts. Conclusion: This
paper is a preliminary report of a genomic study on animal model of
depression which tries to achieve reliable results by a joint of
clinical view with recent techniques. Predicted challenges in this procedure and the solutions as well as the limitations may be helpful for future researches.