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Bioimpacts. 2011;1(3): 179-181.
doi: 10.5681/bi.2011.024
PMID: 23678424
PMCID: PMC3648964
Scopus ID: 84876737243
  Abstract View: 1716
  PDF Download: 1268

Short Communication

Planning Genomic Study in an Animal Model of Depression: a Preliminary Report

Alireza Farnam 1, Ali Fakhari 1, Leila Roshangar 2, Sajjad Kahni 3, Sara Farhang 1*

1 Research Team for Psychiatry and Behavioral Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Anatomy and Histology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 Research Centre for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: dsfarhang@gmail.com

Abstract

Introduction: Interaction of several genes is responsible for psychiatric diseases such as depression. Despite the numerous microarray studies in this field, findings are controversial and hard to conclude. Methods: Male Wistar rats were randomly selected to receive Chronic Mild Stress model for 4 weeks. Different aspects of depression were measured by forced swimming test, open field trial and sucrose preference tests in the experience group and controls. Results: Sucrose was preferred by 40% of CMS group and 80% of controls (p=0.025). Twenty percent of CMS group and 80% of controls were “active” (p=0.001). Last escape was at minute 238 for CMS group and minute 245 for controls and controls had more escape efforts. Conclusion: This paper is a preliminary report of a genomic study on animal model of depression which tries to achieve reliable results by a joint of clinical view with recent techniques. Predicted challenges in this procedure and the solutions as well as the limitations may be helpful for future researches.
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Submitted: 15 May 2011
Revision: 06 Aug 2011
Accepted: 15 Aug 2011
ePublished: 30 Sep 2011
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