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Bioimpacts. 2020;10(3): 177-186.
doi: 10.34172/bi.2020.22
PMID: 32793440
PMCID: PMC7416014
Scopus ID: 85089309823
  Abstract View: 178
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Original Research

The effects of concurrent treatment of silymarin and lactulose on memory changes in cirrhotic male rats

Mozhgan Ghobadi Pour 1 ORCID logo, Naser Mirazi 1* ORCID logo, Hojatollah Alaei 2, Maryam Radahmadi 2, Ziba Rajaei 2, Alireza Monsef Esfahani 3

1 Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan, Iran
2 Department of Physiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding author: Naser Mirazi, Email: Mirazi205@gmail.com Mirazi@basu.ac.ir

Abstract

Introduction: Chronic liver disease frequently accompanied by hepatic encephalopathy (HE). Changes in the permeability of the blood-brain barrier in HE, make an easier entrance of ammonia among other substances to the brain, which leads to neurotransmitter disturbances. Lactulose (LAC), causes better defecation and makes ammonia outreach of blood. Silymarin (SM) is a known standard drug for liver illnesses. The purpose of this research was to determine the results of LAC and SM combined treatment, on the changes in memory of cirrhotic male rats.
Methods: The cirrhotic model established by treatment with thioacetamide (TAA) for 18 weeks. Cirrhotic rats randomized to four groups (n = 7): TAA group (received drinking water), LAC group (2 g/kg/d LAC in drinking water), SM group (50 mg/kg/d SM by food), SM+ LAC group (similar combined doses of both compounds) for 8 weeks. The control group received drinking water. The behavior examined by wire hanging (WH), passive avoidance (PA), and open field (OF) tests.
Results: Our findings showed that treatment with SM+LAC effectively increased PA latency, compared with the control group. The results showed that the administration of LAC and SM+LAC affected the number of lines crossed, the total distance moved and velocity in the OF tests.
Conclusion: SM and LAC have anti-inflammatory effects that are memory changing. It may be due to their useful effects. These results indicated that SM+LAC restored memory disturbance and irritated mood in the cirrhotic rats. Comparable neuroprotection was never previously informed. Such outcomes are extremely promising and indicate the further study of SM+LAC.
Keywords: Behavior, Lactulose, Liver cirrhosis, Memory, Silymarin, Wistar rat
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Submitted: 28 Jul 2019
Revision: 30 Nov 2019
Accepted: 14 Dec 2019
ePublished: 24 Mar 2020
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