1. The effects of concurrent treatment of silymarin and lactulose on memory changes in cirrhotic male rats

Mozhgan Ghobadi Pour , Naser Mirazi* , Hojatollah Alaei, Maryam Radahmadi, Ziba Rajaei, Alireza Monsef Esfahani

Bioimpacts. 2020;10(3): 177-186. doi: 10.34172/bi.2020.22

PMCID: PMC7416014 PMID: 32793440 Scopus ID: 85089309823

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The rat cirrhotic model is made by using thioacetamide hepatotoxin for 18 weeks. The cirrhotic rats treated to some degrees by using lactulose and silymarin known standard drugs for 8 weeks.

Original Article

2. Synthesis, characterization and hepatoprotective effect of silymarin phytosome nanoparticles on ethanol-induced hepatotoxicity in rats

Arezoo Gohari Mahmoudabad , Fatemeh Gheybi, Mohsen Mehrabi* , Alireza Masoudi, Zeinab Mobasher, Hamid Vahedi, Anneh Mohammad Gharravi, Fatemeh Sadat Bitaraf, Seyed Mahdi Rezayat Sorkhabadi

Bioimpacts. 2023;13(4): 301-311. doi: 10.34172/bi.2023.24128

PMCID: PMC10460772 PMID: 37645028 Scopus ID: 85168161377

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Phytosome silymarin nanoparticles effectively improved ethanol-induced liver damage in models of rats with alcoholic liver disease (ALD) and showed higher beneficial effects and less toxicity compared to the bulky form of phytosome silymarin nanoparticles.

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