<script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'UA-48293608-1'); </script>
Logo-bi
Bioimpacts. 2023;13(4): 301-311. doi: 10.34172/bi.2023.24128
PMID: 37645028        PMCID: PMC10460772

Original Article

Synthesis, characterization and hepatoprotective effect of silymarin phytosome nanoparticles on ethanol-induced hepatotoxicity in rats

Arezoo Gohari Mahmoudabad 1,2 ORCID, Fatemeh Gheybi 3, Mohsen Mehrabi 2 * ORCID, Alireza Masoudi 4, Zeinab Mobasher 5, Hamid Vahedi 6,7, Anneh Mohammad Gharravi 8, Fatemeh Sadat Bitaraf 9, Seyed Mahdi Rezayat Sorkhabadi 5

Cited by CrossRef: 9

1- Rana L, Harwansh R, Deshmukh R. Recent Updates on Phytopharmaceuticals-Based Novel Phytosomal Systems and Their Clinical Trial Status: A Translational Perspective . Crit Rev Ther Drug Carrier Syst. 2025;42(1):1 [Crossref]
2- Tay A, Iyer S, Ang T, Ho H, Srinivasan D. Nanotheranostics for alcohol-related liver disease: advances in precision diagnosis and targeted therapy. 2026; [Crossref]
3- Yang Y, Yu Y, Lin K, Lu C. Superior antiglycation efficacy of silymarin from Silybum marianum in human αA-crystallin: Implications for diabetic cataract prevention. 2026;90(4):543 [Crossref]
4- Chen Y, Gao T, Bai J, Yu L, Liu Y, Li Y, Zhang W, Niu S, Liu S, Guo J. Ge-Zhi-Jie-Jiu decoction alleviates alcoholic liver disease through multiple signaling pathways. Journal of Ethnopharmacology. 2025;337:118840 [Crossref]
5- Tawfik M, Hussein Y, Hasanin A, Baher W, El-Khazragy N, Moawad F, El-Khair M, El-Sayed S. Targeting metabolic dysfunction-associated steatotic liver disease with phytosomal silymarin and piperine: A natural alternative to fenofibrate in a rat model. Naunyn-Schmiedeberg's Arch Pharmacol. 2026;399(4):5559 [Crossref]
6- Khabarov I, Sergazy S, Maikenova A, Zhabayeva A, Maslova O, Adekenov S. Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application.. Eurasian Chem-Technol J. 2024;26(4) [Crossref]
7- Nuñez Pereyra C, Sánchez Jiménez C, Pacheco Moisés F, Quiñonez Galván J, Castillo Romero A, Jáuregui Huerta F, Carbajal Arizaga G. Hidróxidos dobles lamelares que contienen lantánidos como plataformas para construir vehículos fluorescentes. rbio. 2026; [Crossref]
8- Rumman M, Khan M. Drug delivery systems for enhanced neuroprotective effects of polyphenols: Current status and challenges. Journal of Drug Delivery Science and Technology. 2026;115:107767 [Crossref]
9- Sun Z, Zhang H, Yeerkenbieke D, Wang L, Zhang Y, Wang C, Kong F, Li Y, Wang D, Li L. Structure and hepatoprotective activity of autophagy-related Butyriboletus roseoflavus polysaccharide. Carbohydrate Polymers. 2026;383:125316 [Crossref]
10- Al-Sheddi E, Farshori N, Al-Oqail M, Alblwi F, Ahmad J, Al-Khedhairy A, Siddiqui M. Hepatoprotective effect of date fruit extract against ethanol-induced apoptosis in human hepatoma (HepG2) cells. Tissue and Cell. 2024;90:102519 [Crossref]
11- Li X, Zhu H, Wang Y, Zhang X, Yang Z, Yan X, Yu Q. Silymarin and Silybin: Rejuvenating Traditional Remedies with Modern Delivery Strategies. Pharmaceutics. 2025;17(12):1628 [Crossref]
12- Telange D, Deshmukh V, Gangane P, More S, Warokar A. Development and Optimization of Double-Loaded Phytosomal Soft Nanoparticles for Enhancing the Biopharmaceutical and Synergistic Hepatoprotective Performance of Silymarin and Curcuminoids. BioNanoSci. 2025;15(3) [Crossref]
13- Mohamed A, Sabry Y, Elmistekawy A, Saaedi T, Omar I, Zaitone S, Mohamed N, Khodeer D, Eltrawy A. Calycosin protects from histopathological and ultrastructural changes in ethanol-induced liver injury and exhibits predicted binding affinity to TNF-α/NF-κB/HIF-1α proteins. Front Pharmacol. 2026;17 [Crossref]
14- Rubina S, Banu Z, Dokuparthi S, Edupuganti S. Phytosomes: Advanced Phospholipid-Based Vesicular Systems for Enhanced Delivery of Phytochemicals. HUJPHARM. 2026;46(2):167 [Crossref]
15- Peres B, Procyuk A, Zelencova A, Kauhova I, Aroyan M, Novikova E. Development of Technology of Phytosubstantiation of Silybum marianum L. Fruits as a Component of Complex Therapy of Liver Diseases. Razrabotka i registraciâ lekarstvennyh sredstv. 2023; [Crossref]

Poster

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate (2025): 19% 
Publication fee: Free of charge

Indexing/Abstracting Info
PubMed; PubMed Central; Scopus; Science Citation Index Expanded; Google Scholar;   SJR; Essential Science Indicators; Embase; EBSCOhost; CAS: DOAJ: SHERPA/RoMEO
Member of   
Follower of ICMJE
Permission: CC BY-NC